A small-molecule membrane fluidizer re-sensitizes methicillin-resistant

Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Anti-Bacterial Agents / pharmacology Monobactams Drug Resistance, Microbial
antibiotic antibiotic adjuvant antimicrobial resistance membrane fluidizer

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
18 10 2023
Historique:
medline: 23 10 2023
pubmed: 8 9 2023
entrez: 8 9 2023
Statut: ppublish

Résumé

Novel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resistance problem. While natural products remain the main source in antibiotic discovery, synthetic antibacterials provide an attractive alternative and may evade the ancient antibiotic resistance. Herein, we report a small molecule that re-sensitizes methicillin-resistant

Identifiants

DOI: 10.1128/aac.00051-23 PMID: 37681969 PMC: PMC10583677
pubmed: 37681969
doi: 10.1128/aac.00051-23
pmc: PMC10583677
doi:

Substances chimiques

Anti-Bacterial Agents 0
Monobactams 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0005123

Subventions

Organisme : NIAID NIH HHS
ID : R33 AI121581
Pays : United States

Déclaration de conflit d'intérêts

J.D.P, J.Z., and X.W. are inventors on a Recreo patent application including the trypyricins (WO/2020/037155) and hold shares in Recreo.

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Auteurs

Jessica D Podoll (JD)

Recreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.

Emma Rosen (E)

Recreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.

Wei Wang (W)

Department of Chemistry, University of Colorado , Boulder, Colorado, USA.

Yuefeng Gao (Y)

Department of Chemistry, University of Colorado , Boulder, Colorado, USA.

Jing Zhang (J)

Recreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.

Xiang Wang (X)

Department of Chemistry, University of Colorado , Boulder, Colorado, USA.
ORCID: 0000-0003-0396-7404

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › A small-molecule membrane fluidizer...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › A small-molecule membrane fluidizer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A small-molecule membrane fluidizer...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Monobactames › A small-molecule membrane fluidizer...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › A small-molecule membrane fluidizer...