An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from
PKPD modeling
antimicrobial combination
ceftazidime/avibactam
colistin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
18 10 2023
18 10 2023
Historique:
medline:
23
10
2023
pubmed:
8
9
2023
entrez:
8
9
2023
Statut:
ppublish
Résumé
In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time. However, TKCs in combination pose interpretation problems. The objective of this study was to characterize the PD interaction over time between ceftazidime/avibactam (CZA) and colistin (CST) using TKC against four multidrug-resistant
Identifiants
pubmed: 37681977
doi: 10.1128/aac.00301-23
pmc: PMC10583682
doi:
Substances chimiques
Ceftazidime
9M416Z9QNR
Colistin
Z67X93HJG1
avibactam
7352665165
Anti-Bacterial Agents
0
Azabicyclo Compounds
0
Drug Combinations
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0030123Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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