Study protocol: A systematic review and meta-analysis regarding the influence of coagulopathy and immune activation on new onset atrial fibrillation in patients with sepsis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
04
2023
accepted:
18
08
2023
medline:
11
9
2023
pubmed:
8
9
2023
entrez:
8
9
2023
Statut:
epublish
Résumé
New onset atrial fibrillation (NOAF) is the most common arrhythmia affecting critically ill patients with sepsis. NOAF is associated with increased intensive care unit mortality, increased hospital mortality, development of heart failure and increased risk of permanent atrial fibrillation and thromboembolic events such as stroke. The pathophysiology of NOAF has been outlined, however, a knowledge gap exists regarding the association between abnormalities in coagulation and immune biomarkers, and the risk of developing NOAF in patients with sepsis. This protocol describes a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guideline (PRISMA-P) and the Meta-Analyses and Systematic Reviews of Observational Studies guideline (MOOSE). We will conduct the literature search in Medline, Scopus and Cochrane Library. We will include studies that report data in adult patients (>18 years) with sepsis that develop NOAF. We will extract data from studies that report at least one coagulation or immune biomarker. Risk of bias will be assessed by using the Newcastle Ottawa Scale (NOS) and Risk of Bias 2 tool (RoB2) for non-randomized and randomized trials respectively. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be utilized in assessing the quality of evidence. This systematic review and meta-analysis will explore the scientific literature regarding the association between coagulation and immune activation in critically ill patients with sepsis, who develop NOAF. The findings will add to the existing knowledge base of NOAF in sepsis, highlight areas of uncertainty and identify future areas of interest to guide and improve management strategies for NOAF. Registration details. CRD42022385225 (PROSPERO).
Sections du résumé
BACKGROUND
New onset atrial fibrillation (NOAF) is the most common arrhythmia affecting critically ill patients with sepsis. NOAF is associated with increased intensive care unit mortality, increased hospital mortality, development of heart failure and increased risk of permanent atrial fibrillation and thromboembolic events such as stroke. The pathophysiology of NOAF has been outlined, however, a knowledge gap exists regarding the association between abnormalities in coagulation and immune biomarkers, and the risk of developing NOAF in patients with sepsis.
METHODS AND ANALYSIS
This protocol describes a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guideline (PRISMA-P) and the Meta-Analyses and Systematic Reviews of Observational Studies guideline (MOOSE). We will conduct the literature search in Medline, Scopus and Cochrane Library. We will include studies that report data in adult patients (>18 years) with sepsis that develop NOAF. We will extract data from studies that report at least one coagulation or immune biomarker. Risk of bias will be assessed by using the Newcastle Ottawa Scale (NOS) and Risk of Bias 2 tool (RoB2) for non-randomized and randomized trials respectively. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be utilized in assessing the quality of evidence.
DISCUSSION
This systematic review and meta-analysis will explore the scientific literature regarding the association between coagulation and immune activation in critically ill patients with sepsis, who develop NOAF. The findings will add to the existing knowledge base of NOAF in sepsis, highlight areas of uncertainty and identify future areas of interest to guide and improve management strategies for NOAF.
TRIAL REGISTRATION
Registration details. CRD42022385225 (PROSPERO).
Identifiants
pubmed: 37683020
doi: 10.1371/journal.pone.0290963
pii: PONE-D-23-10937
pmc: PMC10490925
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0290963Informations de copyright
Copyright: © 2023 Downes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Intensive Care Med. 2019 Jul;45(7):928-938
pubmed: 31089761
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Trends Mol Med. 2011 Oct;17(10):556-63
pubmed: 21763201
BMC Med. 2015 May 06;13:105
pubmed: 25943883
Allergy. 2009 May;64(5):669-77
pubmed: 19210357
JAMA. 2011 Nov 23;306(20):2248-54
pubmed: 22081378
Eur Heart J Acute Cardiovasc Care. 2022 Aug 9;11(8):620-628
pubmed: 35792651
J Intensive Care. 2015 Apr 23;3(1):19
pubmed: 25914828
Am J Respir Crit Care Med. 2017 Jan 15;195(2):205-211
pubmed: 27467907
Intensive Crit Care Nurs. 2021 Dec;67:103114
pubmed: 34373148
BMJ. 2021 Mar 29;372:n160
pubmed: 33781993
J Pers Med. 2022 Mar 30;12(4):
pubmed: 35455662
Crit Care. 2021 Jul 21;25(1):257
pubmed: 34289899
J Crit Care. 2012 Jun;27(3):326.e1-8
pubmed: 22226423
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
J Crit Care. 2019 Oct;53:169-175
pubmed: 31247516
BMJ. 2015 Jan 02;350:g7647
pubmed: 25555855
Minerva Anestesiol. 2011 Oct;77(10):986-92
pubmed: 21952599
Open Inflamm J. 2011 Oct 7;4:4-15
pubmed: 23723956
JAMA Surg. 2021 Aug 1;156(8):787-788
pubmed: 33825847
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Chest. 2018 Dec;154(6):1424-1434
pubmed: 29627355
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Crit Care Med. 2004 Mar;32(3):722-6
pubmed: 15090953
Crit Care. 2010;14(3):R108
pubmed: 20537138