Chronic Deep Brain Stimulation of the Human Nucleus Accumbens Region Disrupts the Stability of Intertemporal Preferences.
chronic effects
cognitive
deep brain stimulation
intertemporal choice
nucleus accumbens
obsessive-compulsive disorder
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
25 10 2023
25 10 2023
Historique:
received:
24
01
2023
revised:
19
06
2023
accepted:
22
06
2023
pmc-release:
25
04
2024
medline:
27
10
2023
pubmed:
9
9
2023
entrez:
8
9
2023
Statut:
ppublish
Résumé
When choosing between rewards that differ in temporal proximity (intertemporal choice), human preferences are typically stable, constituting a clinically relevant transdiagnostic trait. Here we show, in female and male human patients undergoing deep brain stimulation (DBS) of the anterior limb of the internal capsule/NAcc region for treatment-resistant obsessive-compulsive disorder, that long-term chronic (but not phasic) DBS disrupts intertemporal preferences. Hierarchical Bayesian modeling accounting for temporal discounting behavior across multiple time points allowed us to assess both short-term and long-term reliability of intertemporal choice. In controls, temporal discounting was highly reliable, both long-term (6 months) and short-term (1 week). In contrast, in patients undergoing DBS, short-term reliability was high, but long-term reliability (6 months) was severely disrupted. Control analyses confirmed that this effect was not because of range restriction, the presence of obsessive-compulsive disorder symptoms or group differences in choice stochasticity. Model-agnostic between- and within-subject analyses confirmed this effect. These findings provide initial evidence for long-term modulation of cognitive function via DBS and highlight a potential contribution of the human NAcc region to intertemporal preference stability over time.
Identifiants
pubmed: 37684029
pii: JNEUROSCI.0138-23.2023
doi: 10.1523/JNEUROSCI.0138-23.2023
pmc: PMC10601365
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7175-7185Informations de copyright
Copyright © 2023 the authors.
Références
J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):805-812
pubmed: 30770458
Depress Anxiety. 2017 May;34(5):463-470
pubmed: 28009473
Nat Neurosci. 2013 Apr;16(4):386-7
pubmed: 23434914
Psychol Assess. 2002 Dec;14(4):485-96
pubmed: 12501574
Nat Neurosci. 2010 May;13(5):538-9
pubmed: 20348919
Science. 2009 May 1;324(5927):646-8
pubmed: 19407204
Addiction. 2017 Jan;112(1):51-62
pubmed: 27450931
BMC Psychiatry. 2014 Aug 02;14:214
pubmed: 25085317
Psychol Med. 2017 Oct;47(14):2513-2527
pubmed: 28436342
J Neurosci. 2014 Jul 30;34(31):10298-310
pubmed: 25080591
Neuron. 2019 Apr 3;102(1):27-47
pubmed: 30946823
Trends Cogn Sci. 2011 May;15(5):227-39
pubmed: 21497544
Biol Psychiatry. 2019 Dec 1;86(11):836-847
pubmed: 31471038
J Neurol Sci. 2020 Nov 15;418:117149
pubmed: 33002757
Science. 2004 Oct 15;306(5695):503-7
pubmed: 15486304
Brain. 2020 May 1;143(5):1293-1296
pubmed: 32438409
Neurobiol Dis. 2019 Nov;131:104257
pubmed: 30170114
J Neurosci. 2006 Dec 20;26(51):13213-7
pubmed: 17182771
Neurosci Res. 2015 Jan;90:3-14
pubmed: 25269860
Nat Rev Neurol. 2021 Feb;17(2):75-87
pubmed: 33244188
Soc Cogn Affect Neurosci. 2014 Sep;9(9):1289-302
pubmed: 23887811
Psychiatry Res Neuroimaging. 2017 Nov 30;269:97-105
pubmed: 28988149
Behav Anal (Wash D C). 2019 May;19(2):136-149
pubmed: 31552288
Biol Psychiatry. 2014 Apr 15;75(8):653-9
pubmed: 24199665
Int Clin Psychopharmacol. 2011 Nov;26(6):338-40
pubmed: 21857527
PLoS One. 2014 Nov 05;9(11):e111739
pubmed: 25372136
Addiction. 2016 Dec;111(12):2230-2247
pubmed: 27347846
Nat Neurosci. 2007 Dec;10(12):1625-33
pubmed: 17982449
Behav Brain Res. 2009 Sep 14;202(2):272-7
pubmed: 19463712
Biol Psychiatry. 2014 Apr 15;75(8):647-52
pubmed: 23938318
Neuron. 2013 Feb 6;77(3):406-24
pubmed: 23395370
Neuroimage. 2020 Oct 15;220:117138
pubmed: 32634597
Arch Gen Psychiatry. 2010 Oct;67(10):1061-8
pubmed: 20921122
PLoS One. 2014 Jan 22;9(1):e86496
pubmed: 24466120
Psychon Bull Rev. 2009 Jun;16(3):457-62
pubmed: 19451368
JAMA Psychiatry. 2019 Nov 1;76(11):1176-1186
pubmed: 31461131
Mol Psychiatry. 2021 Jan;26(1):60-65
pubmed: 33144712
Neuroimage. 2013 Aug 1;76:412-27
pubmed: 23507394
Neuropharmacology. 2014 Jan;76 Pt B:518-27
pubmed: 23806805
Brain Sci. 2018 Jan 27;8(2):
pubmed: 29382059
Brain. 2015 Dec;138(Pt 12):3496-502
pubmed: 26428667
Biol Psychiatry. 2013 Nov 15;74(10):e27-8
pubmed: 23623188
Ann N Y Acad Sci. 2014 Oct;1327:62-78
pubmed: 25336389
Prog Neurobiol. 2010 Dec;92(4):533-57
pubmed: 20831892
Mol Psychiatry. 2018 May;23(5):1094-1112
pubmed: 29483673
Curr Biol. 2016 Oct 10;26(19):2625-2628
pubmed: 27593380
Psychol Med. 2019 Jan;49(2):190-199
pubmed: 30070191
J Neurosurg. 2019 Aug 1;131(2):333-342
pubmed: 31370011
J Appl Behav Anal. 2003 Winter;36(4):449-58
pubmed: 14768665