Hydrogen Sulfide Improves Outcomes in a Murine Model of Necrotizing Enterocolitis via the Cys440 Residue on Endothelial Nitric Oxide Synthase.

Humans Infant, Newborn Animals Mice Nitric Oxide Synthase Type III Hydrogen Sulfide / pharmacology Enterocolitis, Necrotizing / drug therapy Disease Models, Animal Lung Injury Infant, Newborn, Diseases Nitric Oxide
Hydrogen sulfide Necrotizing enterocolitis Nitric oxide Persulfidation eNOS

Journal

Journal of pediatric surgery
ISSN: 1531-5037
Titre abrégé: J Pediatr Surg
Pays: United States
ID NLM: 0052631

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 16 05 2023
revised: 31 07 2023
accepted: 13 08 2023
medline: 8 11 2023
pubmed: 9 9 2023
entrez: 8 9 2023
Statut: ppublish

Résumé

Hydrogen sulfide (H Necrotizing enterocolitis was induced in 5-day old wild type (WT) and eNOS In WT mice, the administration of GYY4137 significantly improved clinical sickness scores, attenuated intestinal and lung injury, and improved mesenteric perfusion compared to vehicle (p < 0.05). In eNOS GYY4137 administration improves clinical outcomes, attenuates intestinal and lung injury, and improves perfusion in a murine model of necrotizing enterocolitis. The beneficial effects of GYY4137 are dependent on the Cys440 residue of eNOS.

Sections du résumé

BACKGROUND BACKGROUND
Hydrogen sulfide (H
METHODS METHODS
Necrotizing enterocolitis was induced in 5-day old wild type (WT) and eNOS
RESULTS RESULTS
In WT mice, the administration of GYY4137 significantly improved clinical sickness scores, attenuated intestinal and lung injury, and improved mesenteric perfusion compared to vehicle (p < 0.05). In eNOS
CONCLUSIONS CONCLUSIONS
GYY4137 administration improves clinical outcomes, attenuates intestinal and lung injury, and improves perfusion in a murine model of necrotizing enterocolitis. The beneficial effects of GYY4137 are dependent on the Cys440 residue of eNOS.

Identifiants

DOI: 10.1016/j.jpedsurg.2023.08.006 PMID: 37684170
pubmed: 37684170
pii: S0022-3468(23)00475-X
doi: 10.1016/j.jpedsurg.2023.08.006
pii:
doi:

Substances chimiques

Nitric Oxide Synthase Type III EC 1.14.13.39
GYY 4137 0
Hydrogen Sulfide YY9FVM7NSN
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2391-2398

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Chelsea E Hunter (CE)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Fikir M Mesfin (FM)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Krishna Manohar (K)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Jianyun Liu (J)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

W Christopher Shelley (WC)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

John P Brokaw (JP)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Anthony R Pecoraro (AR)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Brian D Hosfield (BD)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Troy A Markel (TA)

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA. Electronic address: tmarkel@iupui.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Eucaryotes › Animaux › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Nitric oxide synthase type III › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Entérocolite › Entérocolite nécrosante › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Plaies et blessures › Blessures du thorax › Lésion pulmonaire › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Hydrogen Sulfide Improves Outcomes in a Murine...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Hydrogen Sulfide Improves Outcomes in a Murine...