The continuation of oral anticoagulation and antiplatelet therapy for dento-alveolar surgery: a service evaluation.


Journal

British dental journal
ISSN: 1476-5373
Titre abrégé: Br Dent J
Pays: England
ID NLM: 7513219

Informations de publication

Date de publication:
09 2023
Historique:
received: 10 03 2023
accepted: 10 07 2023
medline: 11 9 2023
pubmed: 9 9 2023
entrez: 8 9 2023
Statut: ppublish

Résumé

Background Patients taking oral anticoagulants (OACs) and oral antiplatelets (OAPs) have a risk of post-operative bleeding when dental extractions are required. Guidance exists to assist dental practitioners on how best to clinically manage these patients, but this is based upon low-quality evidence. The current service evaluation provides real world clinical data when these drugs are not discontinued for oral surgery procedures.Materials and methods All OACs and OAPs were continued and patients requiring dental extractions had local haemostatic measures (local anaesthesia with adrenaline, socket packing with haemostat and resorbable sutures). All patients were offered a follow-up via a telephone clinic service after surgery to assess any post-operative bleeding.Results A total of 439 patients underwent 513 surgical episodes, equating to 1,001 dental extractions. Overall, 412 (95.9%) patients reported no post-operative bleeding complications. A total of 18 (4.1%) patients reported post-operative bleeding requiring further intervention. All but two patients were managed with local haemostatic measures, and no patient required hospital admission. For the single novel OAC cohort of patients, 8/185 (4.3%) procedures had post-operative bleeding.Conclusion This current service evaluation highlights that the risk of significant or life-threatening bleeding following dental extraction when OACs or OAPs are continued remains rare.

Identifiants

pubmed: 37684457
doi: 10.1038/s41415-023-6227-5
pii: 10.1038/s41415-023-6227-5
doi:

Substances chimiques

Platelet Aggregation Inhibitors 0
Anticoagulants 0
Hemostatics 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

313-318

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to the British Dental Association.

Références

Ho K, van Hove M, Leng G. Trends in anticoagulant prescribing: a review of local policies in English primary care. BMC Health Serv Res 2020; 20: 279.
Scottish Dental Clinical Effectiveness Programme. Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs - New guidance from SDCEP. 2015. Available at https://www.scottishdental.org/management-of-dental-patients-taking-anticoagulants-or-antiplatelet-drugs-new-guidance-from-sdcep/ (accessed August 2023).
Scottish Dental Clinical Effectiveness Programme. Management of Dental Patients Taking Anticoagulant or Antiplatelet Drugs. 2015. Available at https://www.sdcep.org.uk/published-guidance/anticoagulants-and-antiplatelets/ (accessed August 2023).
Wahl M J. Dental surgery in anticoagulated patients. Arch Intern Med 1998; 158: 1610-1616.
Blacker D J, Wijdicks E F, McClelland R L. Stroke risk in anticoagulated patients with atrial fibrillation undergoing endoscopy. Neurology 2003; 61: 964-968.
Yasaka M, Naritomi H, Minematsu K. Ischemic stroke associated with brief cessation of warfarin. Thromb Res 2006; 118: 290-293.
Kitchen L, Erichson R B, Sideropoulos H. Effect of drug-induced platelet dysfunction on surgical bleeding. Am J Surg 1982; 143: 215-217.
Cade J F, Hunt D, Stubbs K P, Gallus A S. Guidelines for the management of oral anticoagulant therapy in patients undergoing surgery. Med J Aust 1979; 2: 292-294.
National Patient Safety Agency. Managing patients who are taking warfarin and undergoing dental treatment. Available at http://www.mfch.cz/wp-content/uploads/2017/04/NHS-antikoagulans.pdf (accessed December 2022).
Woolcombe S A, Ball R E, Patel J P. Managing direct oral anticoagulants in accordance with the Scottish Dental Clinical Effectiveness Programme guidance for patients undergoing dentoalveolar surgery. Br Dent J 2022; 232: 547-554.
Schwarb H, Tsakiris D A. New Direct Oral Anticoagulants (DOAC) and Their Use Today. Dent J (Basel) 2016; 4: 5.
Hasan S S, Kow C S, Curley L E, Baines D L, Babar Z U. Economic evaluation of prescribing conventional and newer oral anticoagulants in older adults. Expert Rev Pharmacoecon Outcomes Res 2018; 18: 371-377.
Davis C, Robertson C, Shivakumar S, Lee M. Implications of Dabigatran, a Direct Thrombin Inhibitor, for Oral Surgery Practice. J Can Dent Assoc 2013; 79: 74.
Johansson K, Götrick B, Holst J, Tranæus S, Naimi-Akbar A. Impact of direct oral anticoagulants on bleeding tendency and postoperative complications in oral surgery: a systematic review of controlled studies. Oral Surg Oral Med Oral Pathol Oral Radiol 2023; 135: 333-346.
Yang S, Shi Q, Liu J, Li J, Xu J. Should oral anticoagulant therapy be continued during dental extraction? A meta-analysis. BMC Oral Health 2016; 16: 81.
Chahine J, Khoudary M, Nasr S. Anticoagulation Use prior to Common Dental Procedures: A Systematic Review. Cardiol Res Pract 2019; DOI: 10.1155/2019/9308631.
Calcia T B, Oballe H J, de Oliveira Silva A M, Friedrich S A, Muniz F W. Is alteration in single drug anticoagulant/antiplatelet regimen necessary in patients who need minor oral surgery? A systematic review with meta-analysis. Clin Oral Investig 2021; 25: 3369-3381.
Manfredi M, Dave B, Percudani D et al. World workshop on oral medicine VII: Direct anticoagulant agents management for invasive oral procedures: A systematic review and meta-analysis. Oral Dis 2019; 25: 157-173.
European Medicines Agency. Annex I: Summary of Product Characteristics. Eliquis. Available at https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf (accessed November 2022).
European Medicines Agency. Annex I: Summary of Product Characteristics. Xarelto. Available at https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf (accessed November 2022).
Dodson T B. Managing anticoagulated patients requiring dental extractions: an exercise in evidence-based clinical practice. Evid Based Dent 2002; 3: 23-26.
Kovich O, Otley C C. Thrombotic complications related to discontinuation of warfarin and aspirin therapy perioperatively for cutaneous operation. J Am Acad Dermatol 2003; 48: 233-237.
Patel N, Patel V, Sarkar D, Nokes T, Blacklock P. Dual anti-platelet therapy and dento-alveolar surgery. How do we manage patients on anti-platelet medication? Br Dent J 2014; DOI: 10.1038/sj.bdj.2014.1055.

Auteurs

Pradeep Sandhu (P)

Speciality Registrar, Oral Surgery, Oral and Maxillofacial Surgery Department, Salisbury District Hospital, United Kingdom.

Serena Mayor (S)

Speciality Dentist, Oral Surgery, Oral Surgery Department, Guy´s and St Thomas´ Hospital, United Kingdom.

Christopher Sproat (C)

Consultant, Oral Surgery, Oral Surgery Department, Guy´s and St Thomas´ Hospital, United Kingdom.

Jerry Kwok (J)

Consultant, Oral Surgery, Oral Surgery Department, Guy´s and St Thomas´ Hospital, United Kingdom.

Kiran Beneng (K)

Consultant, Oral Surgery, Oral Surgery Department, Guy´s and St Thomas´ Hospital, United Kingdom.

Vinod Patel (V)

Consultant, Oral Surgery, Oral Surgery Department, Guy´s and St Thomas´ Hospital, United Kingdom. vinod.patel@hotmail.co.uk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH