The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review.
AhR
aorta
cardiovascular system
endothelial function
endothelium
vascular homeostasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2023
31 Aug 2023
Historique:
received:
25
07
2023
revised:
12
08
2023
accepted:
29
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise current knowledge on the AhR role in the endothelium and its cardiovascular implications. We focus on endogenous AhR agonists, such as some uremic toxins and other agonists unrelated to environmental pollutants, as well as studies using AhR knockout models. We conclude that AhR activation leads to vascular oxidative stress and endothelial dysfunction and that blocking AhR signalling could provide a new target for the treatment of vascular disorders such as cardiovascular complications in patients with chronic kidney disease or pulmonary arterial hypertension.
Identifiants
pubmed: 37686342
pii: ijms241713537
doi: 10.3390/ijms241713537
pmc: PMC10488274
pii:
doi:
Substances chimiques
Receptors, Aryl Hydrocarbon
0
Environmental Pollutants
0
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Chem Biol Interact. 2002 Sep 20;141(1-2):131-60
pubmed: 12213389
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Nature. 2008 May 1;453(7191):65-71
pubmed: 18362915
Chem Biol Interact. 2002 Sep 20;141(1-2):41-61
pubmed: 12213384
Annu Rev Pharmacol Toxicol. 2003;43:309-34
pubmed: 12540743
J Atheroscler Thromb. 2016 Aug 1;23(8):960-75
pubmed: 26860885
Sci Rep. 2017 Jun 8;7(1):3057
pubmed: 28596556
J Mol Evol. 2023 Jul 1;:
pubmed: 37392220
Biol Chem. 2010 Nov;391(11):1235-48
pubmed: 20868221
Nephrol Dial Transplant. 2017 Nov 01;32(11):1809-1817
pubmed: 28379433
Int J Mol Sci. 2016 Aug 03;17(8):
pubmed: 27527145
Circ Res. 2008 Jun 20;102(12):1558-65
pubmed: 18515748
Nature. 2007 Mar 29;446(7135):562-6
pubmed: 17392787
Int J Mol Sci. 2021 Jan 22;22(3):
pubmed: 33499346
Toxicol Appl Pharmacol. 2003 Dec 1;193(2):177-87
pubmed: 14644620
Front Immunol. 2018 Feb 13;9:286
pubmed: 29487603
Chem Res Toxicol. 2008 Jan;21(1):102-16
pubmed: 18076143
Rev Esp Cardiol. 2009 Oct;62(10):1161-78
pubmed: 19793522
Biochem Pharmacol. 2019 Jan;159:116-120
pubmed: 30508524
J Cardiovasc Dis Res. 2011 Apr;2(2):96-103
pubmed: 21814413
Curr Opin Toxicol. 2017 Feb;2:87-92
pubmed: 32296737
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8851-6
pubmed: 17502624
J Atheroscler Thromb. 2014;21(9):904-16
pubmed: 24727683
Phytomedicine. 2021 Nov;92:153751
pubmed: 34563984
Cardiovasc Res. 2009 Mar 1;81(4):669-77
pubmed: 19126602
Life Sci. 2021 Jan 15;265:118807
pubmed: 33232689
Am J Ind Med. 2006 Nov;49(11):875-84
pubmed: 17006952
Br J Pharmacol. 2022 Jun;179(12):2938-2952
pubmed: 34978070
Int J Mol Sci. 2020 Dec 31;22(1):
pubmed: 33396477
Biochem Pharmacol. 2010 Jul 15;80(2):197-204
pubmed: 20359465
Cardiovasc Toxicol. 2003;3(2):153-63
pubmed: 14501033
Crit Care Med. 2004 May;32(5 Suppl):S271-9
pubmed: 15118530
Biochem Pharmacol. 2011 Sep 1;82(5):514-23
pubmed: 21684261
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):
pubmed: 33836606
Reprod Toxicol. 2017 Dec;74:181-188
pubmed: 28986273
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10442-7
pubmed: 10973493
Br J Anaesth. 2004 Jul;93(1):105-13
pubmed: 15121728
Nat Commun. 2022 Oct 26;13(1):6371
pubmed: 36289221
J Am Soc Nephrol. 2015 Apr;26(4):876-87
pubmed: 25145928
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13743-8
pubmed: 9391097
Toxins (Basel). 2022 Jan 26;14(2):
pubmed: 35202128
Int J Mol Sci. 2020 Mar 31;21(7):
pubmed: 32244284
Oxid Med Cell Longev. 2019 Jul 1;2019:8563845
pubmed: 31354915
Mol Pharmacol. 2005 Mar;67(3):714-20
pubmed: 15590894
J Psychopharmacol. 2022 Feb;36(2):191-201
pubmed: 34979820
J Biol Chem. 2017 Jul 28;292(30):12383-12389
pubmed: 28615443
Biochem Pharmacol. 2023 Feb;208:115371
pubmed: 36528068
Annu Rev Cell Dev Biol. 1996;12:55-89
pubmed: 8970722
Kidney Int. 2013 Oct;84(4):733-44
pubmed: 23636172
Ind Health. 2003 Jul;41(3):149-57
pubmed: 12916744
Hypertension. 2008 Mar;51(3):803-9
pubmed: 18212270
Biol Pharm Bull. 2022;45(4):522-527
pubmed: 35370278