Design, Synthesis, and Antimicrobial Activity Evaluation of Ciprofloxacin-Indole Hybrids.
AMR
antibacterial
ciprofloxacin
hybrid
indole
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Aug 2023
29 Aug 2023
Historique:
received:
03
08
2023
revised:
20
08
2023
accepted:
23
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
With the overuse and misuse of antimicrobial drugs, antibacterial resistance is becoming a critical global health problem. New antibacterial agents are effective measures for overcoming the crisis of drug resistance. In this paper, a novel set of ciprofloxacin-indole/acetophenone hybrids was designed, synthesized, and structurally elucidated with the help of NMR and high-resolution mass spectrometry. The in vitro antibacterial activities of these hybrids against gram-positive and gram-negative pathogens, including four multidrug-resistant clinical isolates, were evaluated and compared with those of the parent drug ciprofloxacin (CIP). All the target compounds (MIC = 0.0625-32 μg/mL) exhibited excellent inhibitory activity against the strains tested. Among them,
Identifiants
pubmed: 37687154
pii: molecules28176325
doi: 10.3390/molecules28176325
pmc: PMC10488977
pii:
doi:
Substances chimiques
Ciprofloxacin
5E8K9I0O4U
Anti-Bacterial Agents
0
DNA Gyrase
EC 5.99.1.3
Indoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Jiangxi Provincial Natural Science Foundation
ID : 20202BAB216041
Organisme : Jiangxi Provincial Natural Science Foundation
ID : 20224ACB206044
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