Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs.
CB1 receptor
CB2 receptor
GPCR
cannabilactones
cannabinoids
hexahydrocannabinol
hydrogenation
quinones
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Sep 2023
04 Sep 2023
Historique:
received:
02
08
2023
revised:
23
08
2023
accepted:
27
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam and in late 2021 arose on the drug market in the United States and in some European countries. A background on the discovery, synthesis, and pharmacology studies of hydrogenated and saturated cannabinoids is described. This is harmonized with a summary and comparison of the cannabinoid receptor affinities of various classical, hybrid, and non-classical saturated cannabinoids. A discussion of structure-activity relationships with the four different pharmacophores found in the cannabinoid scaffold is added to this review. According to laboratory studies in vitro, and in several animal species in vivo, HHC is reported to have broadly similar effects to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive substance in cannabis, as demonstrated both in vitro and in several animal species in vivo. However, the effects of HHC treatment have not been studied in humans, and thus a biological profile has not been established.
Identifiants
pubmed: 37687263
pii: molecules28176434
doi: 10.3390/molecules28176434
pmc: PMC10490552
pii:
doi:
Substances chimiques
Cannabinoids
0
Hallucinogens
0
Cannabinoid Receptor Agonists
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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