Macrolide esterases: current threats and opportunities.

Macrolides / chemistry Esterases Anti-Bacterial Agents / pharmacology Lactones Esters Drug Resistance, Bacterial
antibiotic remediation antimicrobial resistance esterase hydrolase macrolide

Journal

Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 14 06 2023
revised: 14 08 2023
accepted: 15 08 2023
medline: 16 11 2023
pubmed: 10 9 2023
entrez: 9 9 2023
Statut: ppublish

Résumé

Antibiotics often contain ester bonds. The macrocyclic lactones of macrolides are pre-eminent examples in which ester bonds are essential to the form and function of antibiotics. Bacterial macrolide esterases that hydrolyze these macrocyclic lactones to confer antimicrobial resistance (AMR) are the topic of this forum. We provide insight into their role in agricultural systems and discuss their emergence and their potential extensibility to bioremediation efforts.

Identifiants

DOI: 10.1016/j.tim.2023.08.008 PMID: 37689489
pubmed: 37689489
pii: S0966-842X(23)00238-X
doi: 10.1016/j.tim.2023.08.008
pii:
doi:

Substances chimiques

Macrolides 0
Esterases EC 3.1.-
Anti-Bacterial Agents 0
Lactones 0
Esters 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1199-1201

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Poonam Dhindwal (P)

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B4.

Iryna Myziuk (I)

Department of Biochemistry, Microbiology, and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5E5.

Antonio Ruzzini (A)

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B4; Department of Biochemistry, Microbiology, and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5E5. Electronic address: antonio.ruzzini@usask.ca.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Macrolide esterases: current threats and opportunities.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Macrolide esterases: current threats and opportunities.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Macrolide esterases: current threats and opportunities.
questionsmedicales.fr › Composés chimiques organiques › Lactones › Macrolide esterases: current threats and opportunities.
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Macrolide esterases: current threats and opportunities.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Macrolide esterases: current threats and opportunities.