Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
02 Sep 2023
Historique:
pubmed: 11 9 2023
medline: 11 9 2023
entrez: 11 9 2023
Statut: epublish

Résumé

Alzheimer's Disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. Here, we investigated the association between AD and both common variants and aggregates of rare coding and noncoding variants in 13,371 individuals of diverse ancestry with whole genome sequence (WGS) data. Pooled-population analyses identified genetic variants in or near

Identifiants

DOI: 10.1101/2023.09.01.23294953 PMID: 37693521 PMC: PMC10491367
pubmed: 37693521
doi: 10.1101/2023.09.01.23294953
pmc: PMC10491367
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072978
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG041689
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058589
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072547
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066509
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG062602
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058654
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG068221
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG052427
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG072577
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG074328
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048927
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG080810
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG070864
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG068753
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States

Déclaration de conflit d'intérêts

Conflicts of Interest None.

Auteurs

Wan-Ping Lee (WP)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Seung Hoan Choi (SH)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Margaret G Shea (MG)

Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA.

Po-Liang Cheng (PL)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Beth A Dombroski (BA)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Achilleas N Pitsillides (AN)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Nancy L Heard-Costa (NL)

Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.

Hui Wang (H)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Katia Bulekova (K)

Research Computing Services, Information Services & Technology, Boston University, Boston, MA, USA.

Amanda B Kuzma (AB)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Yuk Yee Leung (YY)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

John J Farrell (JJ)

Biomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.

Honghuang Lin (H)

Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Adam Naj (A)

Department of Biostatistics, Epidemiology, and Informatics, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Elizabeth E Blue (EE)

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.

Frederick Nusetor (F)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Dongyu Wang (D)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Eric Boerwinkle (E)

Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

William S Bush (WS)

Cleveland Institute for Computational Biology, Cleveland, OH, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

Xiaoling Zhang (X)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Biomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.

Philip L De Jager (PL)

Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.

Josée Dupuis (J)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.

Lindsay A Farrer (LA)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.
Biomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.
Department of Ophthalmology, Department of Medicine, Boston University Medical School, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.

Eden Martin (E)

John P Hussman Institute for Human Genomics, Miami, FL, USA.
John T Macdonald Department of Human Genetics, Miami, FL, USA.
University of Miami Miller School of Medicine, Miami, FL, USA.

Margaret Pericak-Vance (M)

John P Hussman Institute for Human Genomics, Miami, FL, USA.
John T Macdonald Department of Human Genetics, Miami, FL, USA.
University of Miami Miller School of Medicine, Miami, FL, USA.

Sudha Seshadri (S)

Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.

Ellen M Wijsman (EM)

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Li-San Wang (LS)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Gerard D Schellenberg (GD)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Anita L Destefano (AL)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Jonathan L Haines (JL)

Cleveland Institute for Computational Biology, Cleveland, OH, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

Gina M Peloso (GM)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Classifications MeSH