Characterizing Subcortical Structural Heterogeneity in Autism.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
29 Aug 2023
Historique:
pubmed: 11 9 2023
medline: 11 9 2023
entrez: 11 9 2023
Statut: epublish

Résumé

Autism presents with significant phenotypic and neuroanatomical heterogeneity, and neuroimaging studies of the thalamus, globus pallidus and striatum in autism have produced inconsistent and contradictory results. These structures are critical mediators of functions known to be atypical in autism, including sensory gating and motor function. We examined both volumetric and fine-grained localized shape differences in autism using a large (

Identifiants

DOI: 10.1101/2023.08.28.554882 PMID: 37693556 PMC: PMC10491091
pubmed: 37693556
doi: 10.1101/2023.08.28.554882
pmc: PMC10491091
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : Intramural NIH HHS
ID : ZIA MH002794
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest EO is an employee of Genentech, Inc. DGMM has served on advisory Boards to Roche and Servier. He also receives a stipend for editorial work from Springer. M-CL serves as an editor of the journal Autism and has received editorial honorarium from SAGE Publications.

Auteurs

David N MacDonald (DN)

Integrated Program in Neuroscience, McGill University.
Cerebral Imaging Centre, Douglas Mental Health University Institute.

Saashi A Bedford (SA)

Integrated Program in Neuroscience, McGill University.
Cerebral Imaging Centre, Douglas Mental Health University Institute.
Autism Research Centre, Department of Psychiatry, University of Cambridge.

Emily Olafson (E)

Cerebral Imaging Centre, Douglas Mental Health University Institute.
Department of Neuroscience, Weill Cornell Graduate School of Medical Sciences.

Min Tae M Park (MTM)

Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto.

Gabriel A Devenyi (GA)

Cerebral Imaging Centre, Douglas Mental Health University Institute.
Department of Psychiatry, McGill University.

Stephanie Tullo (S)

Integrated Program in Neuroscience, McGill University.
Cerebral Imaging Centre, Douglas Mental Health University Institute.

Raihaan Patel (R)

Cerebral Imaging Centre, Douglas Mental Health University Institute.
Department of Biological and Biomedical Engineering, McGill University.

Evdokia Anagnostou (E)

Holland Bloorview Kids Rehabilitation Hospital.

Simon Baron-Cohen (S)

Autism Research Centre, Department of Psychiatry, University of Cambridge.

Edward T Bullmore (ET)

Brain Mapping Unit, Department of Psychiatry, University of Cambridge.

Lindsay R Chura (LR)

Autism Research Centre, Department of Psychiatry, University of Cambridge.

Michael C Craig (MC)

Institute of Psychiatry, Psychology and Neuroscience, King's College London.
National Autism Unit, Bethlem Royal Hospital, London, UK.

Christine Ecker (C)

Institute of Psychiatry, Psychology and Neuroscience, King's College London.
Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, GoetheUniversity.

Dorothea L Floris (DL)

Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich,Switzerland.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.

Rosemary J Holt (RJ)

Autism Research Centre, Department of Psychiatry, University of Cambridge.

Rhoshel Lenroot (R)

Dept.of Psychiatry and Behavioral Sciences, University of New Mexico.

Jason P Lerch (JP)

Program in Neurosciences and Mental Health, The Hospital for Sick Children.
Department of Medical Biophysics, University of Toronto.
Wellcome Centre for Integrative Neuroimaging, University of Oxford.

Michael V Lombardo (MV)

Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia.

Declan G M Murphy (DGM)

Institute of Psychiatry, Psychology and Neuroscience, King's College London.

Armin Raznahan (A)

Developmental Neurogenomics Unit, Human Genetics Branch, National Institute of MentalHealth.

Amber N V Ruigrok (ANV)

Autism Research Centre, Department of Psychiatry, University of Cambridge.
Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester.

Elizabeth Smith (E)

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital.

Russell T Shinohara (RT)

Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania.
Center for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania.

Michael D Spencer (MD)

Autism Research Centre, Department of Psychiatry, University of Cambridge.

John Suckling (J)

Brain Mapping Unit, Department of Psychiatry, University of Cambridge.

Margot J Taylor (MJ)

Program in Neurosciences and Mental Health, The Hospital for Sick Children.
Diagnostic Imaging, The Hospital for Sick Children.

Audrey Thurm (A)

Section on Behavioral Pediatrics, National Institute of Mental Health.

Meng-Chuan Lai (MC)

Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto.
Autism Research Centre, Department of Psychiatry, University of Cambridge.
Program in Neurosciences and Mental Health, The Hospital for Sick Children.
The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health and Azrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.
Department of Psychiatry, National Taiwan University Hospital and College of Medicine.

M Mallar Chakravarty (MM)

Integrated Program in Neuroscience, McGill University.
Cerebral Imaging Centre, Douglas Mental Health University Institute.
Department of Psychiatry, McGill University.
Department of Biological and Biomedical Engineering, McGill University.

Classifications MeSH