Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
01 Sep 2023
Historique:
pubmed: 11 9 2023
medline: 11 9 2023
entrez: 11 9 2023
Statut: epublish

Résumé

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of

Identifiants

DOI: 10.1101/2023.08.31.555634 PMID: 37693622 PMC: PMC10491179
pubmed: 37693622
doi: 10.1101/2023.08.31.555634
pmc: PMC10491179
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237291
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR024574
Pays : United States
Organisme : NIH HHS
ID : S10 OD028648
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA265748
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS129860
Pays : United States

Déclaration de conflit d'intérêts

Competing Interests: The authors declare they have no competing interests.

Auteurs

Linda Zhang (L)

Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX.
Medical Scientist Training Program, Baylor College of Medicine, Houston, TX.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.

Joanne I Hsu (JI)

Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX.
Medical Scientist Training Program, Baylor College of Medicine, Houston, TX.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.

Etienne D Braekeleer (ED)

Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge.

Chun-Wei Chen (CW)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.
Integrated Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX.

Tajhal D Patel (TD)

Texas Children's Hospital Department of Hematology/Oncology, Baylor College of Medicine, Houston, TX.

Hidetaka Urya (H)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

Anna G Guzman (AG)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

Alejandra G Martell (AG)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

Sarah M Waldvogel (SM)

Medical Scientist Training Program, Baylor College of Medicine, Houston, TX.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.
Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX.

Ayala Tovy (A)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.

Elsa Callen (E)

Laboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, MD.

Rebecca Murdaugh (R)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.
Department of Neurosurgery, Baylor College of Medicine, Houston, TX.

Rosemary Richard (R)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.
Department of Neurosurgery, Baylor College of Medicine, Houston, TX.

Sandra Jansen (S)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

Lisenka Vissers (L)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

Bert B A de Vries (BBA)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

Andre Nussenzweig (A)

Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX.

Shixia Huang (S)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Department of Education, Innovation and Technology, Advanced Technology Cores.

Cristian Coarfa (C)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

Jamie N Anastas (JN)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.
Department of Neurosurgery, Baylor College of Medicine, Houston, TX.

Koichi Takahashi (K)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Department of Education, Innovation and Technology, Advanced Technology Cores.

George Vassiliou (G)

Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge.

Margaret A Goodell (MA)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Houston, TX.

Classifications MeSH