Andre Nussenzweig

Affiliations

Laboratory of Genome Integrity, National Institutes of Health, Bethesda, USA.

Publications (24)

BRCA1 Mutational Complementation Induces Synthetic Viability.

Molecular cell

Avec: Joseph Nacson , Daniela Di Marcantonio , Yifan Wang , Andrea J Bernhardy , Emma Clausen , Xiang Hua , Kathy Q Cai , Esteban Martinez , Wanjuan Feng , Elsa Callén , Wei Wu , Gaorav P Gupta , Joseph R Testa , André Nussenzweig , Stephen M Sykes , Neil Johnson

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Molecular cell

Avec: Andres Canela , Yaakov Maman , Shar-Yin N Huang , Gordana Wutz , Wen Tang , Guido Zagnoli-Vieira , Elsa Callen , Nancy Wong , Amanda Day , Jan-Michael Peters , Keith W Caldecott , Yves Pommier , André Nussenzweig

Role of 53BP1 in end protection and DNA synthesis at DNA breaks.

Genes & development

Avec: Jacob Paiano , Nicholas Zolnerowich , Wei Wu , Raphael Pavani , Chen Wang , Hongzhi Li , Li Zheng , Binghui Shen , Barry P Sleckman , Bo-Ruei Chen , André Nussenzweig

Mechanisms driving chromosomal translocations: lost in time and space.

Oncogene

Avec: Dale A Ramsden , Andre Nussenzweig

bioRxiv : the preprint server for biology

Avec: Linda Zhang , Joanne I Hsu , Etienne D Braekeleer , Chun-Wei Chen , Tajhal D Patel , Hidetaka Urya , Anna G Guzman , Alejandra G Martell , Sarah M Waldvogel , Ayala Tovy , Elsa Callen , Rebecca Murdaugh , Rosemary Richard , Sandra Jansen , Lisenka Vissers , Bert B A de Vries , Andre Nussenzweig , Shixia Huang , Cristian Coarfa , Jamie N Anastas , Koichi Takahashi , George Vassiliou , Margaret A Goodell

Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization.

Nature structural & molecular biology

Avec: Jennifer Zagelbaum , Allana Schooley , Junfei Zhao , Benjamin R Schrank , Elsa Callen , Shan Zha , Max E Gottesman , André Nussenzweig , Raul Rabadan , Job Dekker , Jean Gautier

Nascent DNA sequencing and its diverse applications in genome integrity research.

Methods in cell biology

Avec: Jacob Paiano , André Nussenzweig

Structure and repair of replication-coupled DNA breaks.

Science (New York, N.Y.)

Avec: Raphael Pavani , Veenu Tripathi , Kyle B Vrtis , Dali Zong , Raj Chari , Elsa Callen , Ajith V Pankajam , Gang Zhen , Gabriel Matos-Rodrigues , Jiajie Yang , Shuheng Wu , Giordano Reginato , Wei Wu , Peter Cejka , Johannes C Walter , André Nussenzweig

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.

Nature communications

Avec: Jacob Paiano , Wei Wu , Shintaro Yamada , Nicholas Sciascia , Elsa Callen , Ana Paola Cotrim , Rajashree A Deshpande , Yaakov Maman , Amanda Day , Tanya T Paull , André Nussenzweig

A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.

JCI insight

Avec: Mianmian Yin , Timour Baslan , Robert L Walker , Yuelin J Zhu , Amy Freeland , Toshihiro Matsukawa , Sriram Sridharan , André Nussenzweig , Steven C Pruitt , Scott W Lowe , Paul S Meltzer , Peter D Aplan

Neuronal enhancers are hotspots for DNA single-strand break repair.

Nature

Avec: Wei Wu , Sarah E Hill , William J Nathan , Jacob Paiano , Elsa Callen , Dongpeng Wang , Kenta Shinoda , Niek van Wietmarschen , Jennifer M Colón-Mercado , Dali Zong , Raffaella De Pace , Han-Yu Shih , Steve Coon , Maia Parsadanian , Raphael Pavani , Hana Hanzlikova , Solji Park , Seol Kyoung Jung , Peter J McHugh , Andres Canela , Chongyi Chen , Rafael Casellas , Keith W Caldecott , Michael E Ward , André Nussenzweig

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.

Disease models & mechanisms

Avec: Daniel Bronder , Anthony Tighe , Darawalee Wangsa , Dali Zong , Thomas J Meyer , René Wardenaar , Paul Minshall , Daniela Hirsch , Kerstin Heselmeyer-Haddad , Louisa Nelson , Diana Spierings , Joanne C McGrail , Maggie Cam , André Nussenzweig , Floris Foijer , Thomas Ried , Stephen S Taylor

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

Nature communications

Avec: Diana Zatreanu , Helen M R Robinson , Omar Alkhatib , Marie Boursier , Harry Finch , Lerin Geo , Diego Grande , Vera Grinkevich , Robert A Heald , Sophie Langdon , Jayesh Majithiya , Claire McWhirter , Niall M B Martin , Shaun Moore , Joana Neves , Eeson Rajendra , Marco Ranzani , Theresia Schaedler , Martin Stockley , Kimberley Wiggins , Rachel Brough , Sandhya Sridhar , Aditi Gulati , Nan Shao , Luned M Badder , Daniela Novo , Eleanor G Knight , Rebecca Marlow , Syed Haider , Elsa Callen , Graeme Hewitt , Joost Schimmel , Remko Prevo , Christina Alli , Amanda Ferdinand , Cameron Bell , Peter Blencowe , Chris Bot , Mathew Calder , Mark Charles , Jayne Curry , Tennyson Ekwuru , Katherine Ewings , Wojciech Krajewski , Ellen MacDonald , Hollie McCarron , Leon Pang , Chris Pedder , Laurent Rigoreau , Martin Swarbrick , Ed Wheatley , Simon Willis , Ai Ching Wong , Andre Nussenzweig , Marcel Tijsterman , Andrew Tutt , Simon J Boulton , Geoff S Higgins , Stephen J Pettitt , Graeme C M Smith , Christopher J Lord

CTCF is a barrier for 2C-like reprogramming.

Nature communications

Avec: Teresa Olbrich , Maria Vega-Sendino , Desiree Tillo , Wei Wu , Nicholas Zolnerowich , Raphael Pavani , Andy D Tran , Catherine N Domingo , Mariajose Franco , Marta Markiewicz-Potoczny , Gianluca Pegoraro , Peter C FitzGerald , Michael J Kruhlak , Eros Lazzerini-Denchi , Elphege P Nora , André Nussenzweig , Sergio Ruiz

The mission to ensure continued funding for excellent basic research.

EMBO reports

Avec: Angus I Lamond , Ivan Dikic , Andre Nussenzweig , Christoph W Müller , Janet M Thornton , Michael B Yaffe

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells.

bioRxiv : the preprint server for biology

Avec: B van de Kooij , A Schreuder , R S Pavani , V Garzero , A Van Hoeck , M San Martin Alonso , D Koerse , T J Wendel , E Callen , J Boom , H Mei , E Cuppen , A Nussenzweig , H van Attikum , S M Noordermeer

eLife

Avec: Linda Zhang , Joanne I Hsu , Etienne D Braekeleer , Chun-Wei Chen , Tajhal D Patel , Alejandra G Martell , Anna G Guzman , Katharina Wohlan , Sarah M Waldvogel , Hidetaka Uryu , Ayala Tovy , Elsa Callen , Rebecca L Murdaugh , Rosemary Richard , Sandra Jansen , Lisenka Vissers , Bert B A de Vries , Andre Nussenzweig , Shixia Huang , Cristian Coarfa , Jamie Anastas , Koichi Takahashi , George Vassiliou , Margaret A Goodell

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

Nature

Avec: Niek van Wietmarschen , Sriram Sridharan , William J Nathan , Anthony Tubbs , Edmond M Chan , Elsa Callen , Wei Wu , Frida Belinky , Veenu Tripathi , Nancy Wong , Kyla Foster , Javad Noorbakhsh , Kiran Garimella , Abimael Cruz-Migoni , Joshua A Sommers , Yongqing Huang , Ashir A Borah , Jonathan T Smith , Jeremie Kalfon , Nikolas Kesten , Kasper Fugger , Robert L Walker , Egor Dolzhenko , Michael A Eberle , Bruce E Hayward , Karen Usdin , Catherine H Freudenreich , Robert M Brosh , Stephen C West , Peter J McHugh , Paul S Meltzer , Adam J Bass , André Nussenzweig

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Molecular cell

Avec: Dali Zong , Salomé Adam , Yifan Wang , Hiroyuki Sasanuma , Elsa Callén , Matilde Murga , Amanda Day , Michael J Kruhlak , Nancy Wong , Meagan Munro , Arnab Ray Chaudhuri , Baktiar Karim , Bing Xia , Shunichi Takeda , Neil Johnson , Daniel Durocher , André Nussenzweig

RNA: a double-edged sword in genome maintenance.

Nature reviews. Genetics

Avec: Dali Zong , Philipp Oberdoerffer , Pedro J Batista , André Nussenzweig

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Yafeng He , Jianke Ren , Xiaoping Xu , Kai Ni , Andrew Schwader , Richard Finney , Can Wang , Lei Sun , Kimberly Klarmann , Jonathan Keller , Anthony Tubbs , Andre Nussenzweig , Kathrin Muegge

Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Rüdiger Braun , Lena Anthuber , Daniela Hirsch , Darawalee Wangsa , Justin Lack , Nicole E McNeil , Kerstin Heselmeyer-Haddad , Irianna Torres , Danny Wangsa , Markus A Brown , Anthony Tubbs , Noam Auslander , E Michael Gertz , Philip R Brauer , Margaret C Cam , Dan L Sackett , Jens K Habermann , Andre Nussenzweig , Eytan Ruppin , Zhongqiu Zhang , Daniel W Rosenberg , Thomas Ried

Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.

eLife

Avec: Mohamed Mahgoub , Jacob Paiano , Melania Bruno , Wei Wu , Sarath Pathuri , Xing Zhang , Sherry Ralls , Xiaodong Cheng , André Nussenzweig , Todd S Macfarlan

Two mechanisms of chromosome fragility at replication-termination sites in bacteria.

Science advances

Avec: Qian Mei , Devon M Fitzgerald , Jingjing Liu , Jun Xia , John P Pribis , Yin Zhai , Ralf B Nehring , Jacob Paiano , Heyuan Li , Andre Nussenzweig , P J Hastings , Susan M Rosenberg

Réseau de co-auteurs

André Nussenzweig 15 collaborations

Elsa Callen 9 collaborations

Wei Wu 8 collaborations

Jacob Paiano 6 collaborations

Dali Zong 5 collaborations

Raphael Pavani 4 collaborations

Nancy Wong 3 collaborations

Amanda Day 3 collaborations

Anthony Tubbs 3 collaborations

Yifan Wang 2 collaborations

Elsa Callén 2 collaborations

Neil Johnson 2 collaborations

Andres Canela 2 collaborations

Yaakov Maman 2 collaborations

Keith W Caldecott 2 collaborations

Nicholas Zolnerowich 2 collaborations

Linda Zhang 2 collaborations

Joanne I Hsu 2 collaborations

Etienne D Braekeleer 2 collaborations

Chun-Wei Chen 2 collaborations

Tajhal D Patel 2 collaborations

Anna G Guzman 2 collaborations

Alejandra G Martell 2 collaborations

Sarah M Waldvogel 2 collaborations

Ayala Tovy 2 collaborations

Rosemary Richard 2 collaborations

Sandra Jansen 2 collaborations

Lisenka Vissers 2 collaborations

Bert B A de Vries 2 collaborations

Shixia Huang 2 collaborations

Cristian Coarfa 2 collaborations

Koichi Takahashi 2 collaborations

George Vassiliou 2 collaborations

Margaret A Goodell 2 collaborations

Veenu Tripathi 2 collaborations

Robert L Walker 2 collaborations

Sriram Sridharan 2 collaborations

Paul S Meltzer 2 collaborations

William J Nathan 2 collaborations

Niek van Wietmarschen 2 collaborations

Peter J McHugh 2 collaborations

Darawalee Wangsa 2 collaborations

Daniela Hirsch 2 collaborations

Kerstin Heselmeyer-Haddad 2 collaborations

Thomas Ried 2 collaborations

Michael J Kruhlak 2 collaborations

Joseph Nacson 1 collaboration

Daniela Di Marcantonio 1 collaboration

Andrea J Bernhardy 1 collaboration

Emma Clausen 1 collaboration

Xiang Hua 1 collaboration

Kathy Q Cai 1 collaboration

Esteban Martinez 1 collaboration

Wanjuan Feng 1 collaboration

Gaorav P Gupta 1 collaboration

Joseph R Testa 1 collaboration

Stephen M Sykes 1 collaboration

Shar-Yin N Huang 1 collaboration

Gordana Wutz 1 collaboration

Wen Tang 1 collaboration

Guido Zagnoli-Vieira 1 collaboration

Jan-Michael Peters 1 collaboration

Yves Pommier 1 collaboration

Chen Wang 1 collaboration

Hongzhi Li 1 collaboration

Li Zheng 1 collaboration

Binghui Shen 1 collaboration

Barry P Sleckman 1 collaboration

Bo-Ruei Chen 1 collaboration

Dale A Ramsden 1 collaboration

Hidetaka Urya 1 collaboration

Rebecca Murdaugh 1 collaboration

Jamie N Anastas 1 collaboration

Jennifer Zagelbaum 1 collaboration

Allana Schooley 1 collaboration

Junfei Zhao 1 collaboration

Benjamin R Schrank 1 collaboration

Shan Zha 1 collaboration

Max E Gottesman 1 collaboration

Raul Rabadan 1 collaboration

Job Dekker 1 collaboration

Jean Gautier 1 collaboration

Kyle B Vrtis 1 collaboration

Raj Chari 1 collaboration

Ajith V Pankajam 1 collaboration

Gang Zhen 1 collaboration

Gabriel Matos-Rodrigues 1 collaboration

Jiajie Yang 1 collaboration

Shuheng Wu 1 collaboration

Giordano Reginato 1 collaboration

Peter Cejka 1 collaboration

Johannes C Walter 1 collaboration

Shintaro Yamada 1 collaboration

Nicholas Sciascia 1 collaboration

Ana Paola Cotrim 1 collaboration

Rajashree A Deshpande 1 collaboration

Tanya T Paull 1 collaboration

Mianmian Yin 1 collaboration

Timour Baslan 1 collaboration

Yuelin J Zhu 1 collaboration

Amy Freeland 1 collaboration

Toshihiro Matsukawa 1 collaboration

Steven C Pruitt 1 collaboration

Scott W Lowe 1 collaboration

Peter D Aplan 1 collaboration

Sarah E Hill 1 collaboration

Dongpeng Wang 1 collaboration

Kenta Shinoda 1 collaboration

Jennifer M Colón-Mercado 1 collaboration

Raffaella De Pace 1 collaboration

Han-Yu Shih 1 collaboration

Steve Coon 1 collaboration

Maia Parsadanian 1 collaboration

Hana Hanzlikova 1 collaboration

Solji Park 1 collaboration

Seol Kyoung Jung 1 collaboration

Chongyi Chen 1 collaboration

Rafael Casellas 1 collaboration

Michael E Ward 1 collaboration

Daniel Bronder 1 collaboration

Anthony Tighe 1 collaboration

Thomas J Meyer 1 collaboration

René Wardenaar 1 collaboration

Paul Minshall 1 collaboration

Louisa Nelson 1 collaboration

Diana Spierings 1 collaboration

Joanne C McGrail 1 collaboration

Maggie Cam 1 collaboration

Floris Foijer 1 collaboration

Stephen S Taylor 1 collaboration

Diana Zatreanu 1 collaboration

Helen M R Robinson 1 collaboration

Omar Alkhatib 1 collaboration

Marie Boursier 1 collaboration

Harry Finch 1 collaboration

Lerin Geo 1 collaboration

Diego Grande 1 collaboration

Vera Grinkevich 1 collaboration

Robert A Heald 1 collaboration

Sophie Langdon 1 collaboration

Jayesh Majithiya 1 collaboration

Claire McWhirter 1 collaboration

Niall M B Martin 1 collaboration

Shaun Moore 1 collaboration

Joana Neves 1 collaboration

Eeson Rajendra 1 collaboration

Marco Ranzani 1 collaboration

Theresia Schaedler 1 collaboration

Martin Stockley 1 collaboration

Kimberley Wiggins 1 collaboration

Rachel Brough 1 collaboration

Sandhya Sridhar 1 collaboration

Aditi Gulati 1 collaboration

Nan Shao 1 collaboration

Luned M Badder 1 collaboration

Daniela Novo 1 collaboration

Eleanor G Knight 1 collaboration

Rebecca Marlow 1 collaboration

Syed Haider 1 collaboration

Graeme Hewitt 1 collaboration

Joost Schimmel 1 collaboration

Remko Prevo 1 collaboration

Christina Alli 1 collaboration

Amanda Ferdinand 1 collaboration

Cameron Bell 1 collaboration

Peter Blencowe 1 collaboration

Chris Bot 1 collaboration

Mathew Calder 1 collaboration

Mark Charles 1 collaboration

Jayne Curry 1 collaboration

Tennyson Ekwuru 1 collaboration

Katherine Ewings 1 collaboration

Wojciech Krajewski 1 collaboration

Ellen MacDonald 1 collaboration

Hollie McCarron 1 collaboration

Leon Pang 1 collaboration

Chris Pedder 1 collaboration

Laurent Rigoreau 1 collaboration

Martin Swarbrick 1 collaboration

Ed Wheatley 1 collaboration

Simon Willis 1 collaboration

Ai Ching Wong 1 collaboration

Marcel Tijsterman 1 collaboration

Andrew Tutt 1 collaboration

Simon J Boulton 1 collaboration

Geoff S Higgins 1 collaboration

Stephen J Pettitt 1 collaboration

Graeme C M Smith 1 collaboration

Christopher J Lord 1 collaboration

Teresa Olbrich 1 collaboration

Maria Vega-Sendino 1 collaboration

Desiree Tillo 1 collaboration

Andy D Tran 1 collaboration

Catherine N Domingo 1 collaboration

Mariajose Franco 1 collaboration

Marta Markiewicz-Potoczny 1 collaboration

Gianluca Pegoraro 1 collaboration

Peter C FitzGerald 1 collaboration

Eros Lazzerini-Denchi 1 collaboration

Elphege P Nora 1 collaboration

Sergio Ruiz 1 collaboration

Angus I Lamond 1 collaboration

Ivan Dikic 1 collaboration

Christoph W Müller 1 collaboration

Janet M Thornton 1 collaboration

Michael B Yaffe 1 collaboration

B van de Kooij 1 collaboration

A Schreuder 1 collaboration

R S Pavani 1 collaboration

V Garzero 1 collaboration

A Van Hoeck 1 collaboration

M San Martin Alonso 1 collaboration

D Koerse 1 collaboration

T J Wendel 1 collaboration

E Callen 1 collaboration

J Boom 1 collaboration

H Mei 1 collaboration

E Cuppen 1 collaboration

A Nussenzweig 1 collaboration

H van Attikum 1 collaboration

S M Noordermeer 1 collaboration

Katharina Wohlan 1 collaboration

Hidetaka Uryu 1 collaboration

Rebecca L Murdaugh 1 collaboration

Jamie Anastas 1 collaboration

Edmond M Chan 1 collaboration

Frida Belinky 1 collaboration

Kyla Foster 1 collaboration

Javad Noorbakhsh 1 collaboration

Kiran Garimella 1 collaboration

Abimael Cruz-Migoni 1 collaboration

Joshua A Sommers 1 collaboration

Yongqing Huang 1 collaboration

Ashir A Borah 1 collaboration

Jonathan T Smith 1 collaboration

Jeremie Kalfon 1 collaboration

Nikolas Kesten 1 collaboration

Kasper Fugger 1 collaboration

Egor Dolzhenko 1 collaboration

Michael A Eberle 1 collaboration

Bruce E Hayward 1 collaboration

Karen Usdin 1 collaboration

Catherine H Freudenreich 1 collaboration

Robert M Brosh 1 collaboration

Stephen C West 1 collaboration

Adam J Bass 1 collaboration

Salomé Adam 1 collaboration

Hiroyuki Sasanuma 1 collaboration

Matilde Murga 1 collaboration

Meagan Munro 1 collaboration

Arnab Ray Chaudhuri 1 collaboration

Baktiar Karim 1 collaboration

Bing Xia 1 collaboration

Shunichi Takeda 1 collaboration

Daniel Durocher 1 collaboration

Philipp Oberdoerffer 1 collaboration

Pedro J Batista 1 collaboration

Yafeng He 1 collaboration

Jianke Ren 1 collaboration

Xiaoping Xu 1 collaboration

Kai Ni 1 collaboration

Andrew Schwader 1 collaboration

Richard Finney 1 collaboration

Can Wang 1 collaboration

Lei Sun 1 collaboration

Kimberly Klarmann 1 collaboration

Jonathan Keller 1 collaboration

Kathrin Muegge 1 collaboration

Rüdiger Braun 1 collaboration

Lena Anthuber 1 collaboration

Justin Lack 1 collaboration

Nicole E McNeil 1 collaboration

Irianna Torres 1 collaboration

Danny Wangsa 1 collaboration

Markus A Brown 1 collaboration

Noam Auslander 1 collaboration

E Michael Gertz 1 collaboration

Philip R Brauer 1 collaboration

Margaret C Cam 1 collaboration

Dan L Sackett 1 collaboration

Jens K Habermann 1 collaboration

Eytan Ruppin 1 collaboration

Zhongqiu Zhang 1 collaboration

Daniel W Rosenberg 1 collaboration

Mohamed Mahgoub 1 collaboration

Melania Bruno 1 collaboration

Sarath Pathuri 1 collaboration

Xing Zhang 1 collaboration

Sherry Ralls 1 collaboration

Xiaodong Cheng 1 collaboration

Todd S Macfarlan 1 collaboration

Qian Mei 1 collaboration

Devon M Fitzgerald 1 collaboration

Jingjing Liu 1 collaboration

Jun Xia 1 collaboration

John P Pribis 1 collaboration

Yin Zhai 1 collaboration

Ralf B Nehring 1 collaboration

Heyuan Li 1 collaboration

P J Hastings 1 collaboration

Susan M Rosenberg 1 collaboration