Repeat expansions confer WRN dependence in microsatellite-unstable cancers.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2020
Historique:
received: 20 04 2020
accepted: 16 07 2020
pubmed: 2 10 2020
medline: 15 12 2020
entrez: 1 10 2020
Statut: ppublish

Résumé

The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair

Identifiants

pubmed: 32999459
doi: 10.1038/s41586-020-2769-8
pii: 10.1038/s41586-020-2769-8
pmc: PMC8916167
mid: NIHMS1781309
doi:

Substances chimiques

DNA-Binding Proteins 0
Recombinases 0
ATR protein, human EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins EC 2.7.11.1
Eme1 protein, human EC 3.1.-
Endodeoxyribonucleases EC 3.1.-
Endonucleases EC 3.1.-
MUS81 protein, human EC 3.1.-
SLX4 protein, human EC 3.1.-
WRN protein, human EC 3.6.4.12
Werner Syndrome Helicase EC 3.6.4.12

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

292-298

Subventions

Organisme : European Research Council
Pays : International
Organisme : Medical Research Council
ID : MR/R009368/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : ZIA BC010959
Pays : United States
Organisme : Wellcome Trust
ID : MR/R009368/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM122880
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Niek van Wietmarschen (N)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Sriram Sridharan (S)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

William J Nathan (WJ)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Anthony Tubbs (A)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Edmond M Chan (EM)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Elsa Callen (E)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Wei Wu (W)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Frida Belinky (F)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Veenu Tripathi (V)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Nancy Wong (N)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Kyla Foster (K)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Javad Noorbakhsh (J)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Kiran Garimella (K)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Abimael Cruz-Migoni (A)

Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Joshua A Sommers (JA)

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA.

Yongqing Huang (Y)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Ashir A Borah (AA)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Jonathan T Smith (JT)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Jeremie Kalfon (J)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Nikolas Kesten (N)

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, MA, USA.

Kasper Fugger (K)

DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK.

Robert L Walker (RL)

Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

Egor Dolzhenko (E)

Illumina Inc., San Diego, CA, USA.

Michael A Eberle (MA)

Illumina Inc., San Diego, CA, USA.

Bruce E Hayward (BE)

Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.

Karen Usdin (K)

Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.

Catherine H Freudenreich (CH)

Department of Biology, Tufts University, Medford, MA, USA.

Robert M Brosh (RM)

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA.

Stephen C West (SC)

DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK.

Peter J McHugh (PJ)

Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Paul S Meltzer (PS)

Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

Adam J Bass (AJ)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.

André Nussenzweig (A)

Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.

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