Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Ataxia Telangiectasia Mutated Proteins
/ metabolism
Cell Line, Tumor
Chromosomes, Human
/ genetics
Chromothripsis
DNA Breaks, Double-Stranded
DNA Cleavage
DNA Repeat Expansion
/ genetics
DNA Replication
DNA-Binding Proteins
/ metabolism
Dinucleotide Repeats
/ genetics
Endodeoxyribonucleases
/ metabolism
Endonucleases
/ metabolism
Genomic Instability
Humans
Neoplasms
/ genetics
Recombinases
/ metabolism
Werner Syndrome Helicase
/ metabolism
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
20
04
2020
accepted:
16
07
2020
pubmed:
2
10
2020
medline:
15
12
2020
entrez:
1
10
2020
Statut:
ppublish
Résumé
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair
Identifiants
pubmed: 32999459
doi: 10.1038/s41586-020-2769-8
pii: 10.1038/s41586-020-2769-8
pmc: PMC8916167
mid: NIHMS1781309
doi:
Substances chimiques
DNA-Binding Proteins
0
Recombinases
0
ATR protein, human
EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Eme1 protein, human
EC 3.1.-
Endodeoxyribonucleases
EC 3.1.-
Endonucleases
EC 3.1.-
MUS81 protein, human
EC 3.1.-
SLX4 protein, human
EC 3.1.-
WRN protein, human
EC 3.6.4.12
Werner Syndrome Helicase
EC 3.6.4.12
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
292-298Subventions
Organisme : European Research Council
Pays : International
Organisme : Medical Research Council
ID : MR/R009368/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : ZIA BC010959
Pays : United States
Organisme : Wellcome Trust
ID : MR/R009368/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM122880
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
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