Protein Phosphatase 2C / metabolism Humans Superoxide Dismutase-1 / genetics Cell Line, Tumor Leukemia / genetics CRISPR-Cas Systems Oxidative Stress Reactive Oxygen Species / metabolism Synthetic Lethal Mutations Mutation
DNA damage cancer cancer biology cell biology leukemia mouse

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
18 Jun 2024
Historique:
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg

Identifiants

DOI: 10.7554/eLife.91611 PMID: 38896450
pubmed: 38896450
doi: 10.7554/eLife.91611
pii: 91611
doi:
pii:

Substances chimiques

Protein Phosphatase 2C EC 3.1.3.16
PPM1D protein, human EC 3.1.3.16
Superoxide Dismutase-1 EC 1.15.1.1
SOD1 protein, human 0
Reactive Oxygen Species 0

Banques de données

GEO
['GSE240874']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01CA237291
Pays : United States
Organisme : NCI NIH HHS
ID : P01CA265748
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30DK116428
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health & Human Development
ID : F30HD111129
Organisme : Leukemia and Lymphoma Society
ID : Scholar Award
Organisme : NCI NIH HHS
ID : P30CA125123
Pays : United States

Déclaration de conflit d'intérêts

LZ, JH, EB, CC, TP, AM, AG, KW, SW, HU, AT, EC, RM, RR, SJ, LV, Bd, AN, SH, CC, JA, KT, GV, MG No competing interests declared

Auteurs

Linda Zhang (L)

Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, United States.
Medical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
ORCID: 0000-0002-5777-2357

Joanne I Hsu (JI)

Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, United States.
Medical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.

Etienne D Braekeleer (ED)

Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

Chun-Wei Chen (CW)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
Integrated Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, United States.

Tajhal D Patel (TD)

Texas Children's Hospital Department of Hematology/Oncology, Baylor College of Medicine, Houston, United States.

Alejandra G Martell (AG)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

Anna G Guzman (AG)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

Katharina Wohlan (K)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

Sarah M Waldvogel (SM)

Medical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, United States.

Hidetaka Uryu (H)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States.
ORCID: 0000-0001-7167-895X

Ayala Tovy (A)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.

Elsa Callen (E)

Laboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, United States.

Rebecca L Murdaugh (RL)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
Department of Neurosurgery, Baylor College of Medicine, Houston, United States.

Rosemary Richard (R)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
Department of Neurosurgery, Baylor College of Medicine, Houston, United States.

Sandra Jansen (S)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.

Lisenka Vissers (L)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.

Bert B A de Vries (BBA)

Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.

Andre Nussenzweig (A)

Laboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, United States.

Shixia Huang (S)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Department of Education, Innovation and Technology, Advanced Technology Cores, University of Texas, Houston, United States.

Cristian Coarfa (C)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

Jamie Anastas (J)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
Department of Neurosurgery, Baylor College of Medicine, Houston, United States.

Koichi Takahashi (K)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States.
Department of Genome Medicine, The University of Texas MD Anderson Cancer Center, Houston, United States.

George Vassiliou (G)

Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0003-4337-8022

Margaret A Goodell (MA)

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Center for Cell and Gene Therapy, Houston, United States.
ORCID: 0000-0003-1111-2932

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein phosphatase 2C ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 ›
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale ›
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies ›
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas ›
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif ›
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène ›
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutations synthétiques létales ›
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation ›