Mechanisms driving chromosomal translocations: lost in time and space.


Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
06 2021
Historique:
received: 02 02 2021
accepted: 21 05 2021
revised: 07 05 2021
pubmed: 10 6 2021
medline: 22 12 2021
entrez: 9 6 2021
Statut: ppublish

Résumé

Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it is important to understand the mechanisms leading to these chromosome rearrangements. We review how characteristics of the sources and the cellular responses to chromosome breaks contribute to the accumulation of multiple chromosome breaks at the same moment in time. We also discuss the important role for chromosome break location; how translocation potential is impacted by the location of chromosome breaks both within chromatin and within the nucleus, as well as the effect of altered mobility of chromosome breaks. A common theme in work addressing both temporal and spatial contributions to translocation is that there is no shortage of examples of factors that promote translocation in one context, but have no impact or the opposite impact in another. Accordingly, a clear message for future work on translocation mechanism is that unlike normal DNA metabolic pathways, it isn't easily modeled as a simple, linear pathway that is uniformly followed regardless of differing cellular contexts.

Identifiants

pubmed: 34103687
doi: 10.1038/s41388-021-01856-9
pii: 10.1038/s41388-021-01856-9
pmc: PMC8238880
mid: NIHMS1707605
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4263-4270

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : Intramural Research Program
Organisme : NCI NIH HHS
ID : R01 CA222092
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA247773
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA097096
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA097096
Pays : United States

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Auteurs

Dale A Ramsden (DA)

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dale_ramsden@med.unc.edu.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dale_ramsden@med.unc.edu.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dale_ramsden@med.unc.edu.

Andre Nussenzweig (A)

Laboratory of Genome Integrity, National Institutes of Health, Bethesda, USA.

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