Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.
Journal
Pain research & management
ISSN: 1918-1523
Titre abrégé: Pain Res Manag
Pays: United States
ID NLM: 9612504
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
04
2023
revised:
15
07
2023
accepted:
11
08
2023
medline:
12
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Deficits in voluntary activation of the core stabilizing muscles are consistently observed in patients with chronic low back pain (CLBP); however, the underlying neural mechanism remains unclear. This cross-sectional study aimed at testing the hypothesis that the impaired voluntary activation of core stabilizing muscles is associated with structural and functional alterations in the basal ganglia, thalamus, and cortex in patients with CLBP. We obtained structural and resting-state functional magnetic resonance imaging (rs-fMRI) data from 53 patients with CLBP and 67 healthy controls and estimated the alterations in grey matter volume (GMV) and functional and effective connectivity (EC) of regions with altered GMV via whole brain analysis. The voluntary activation of the multifidus (MF) and transversus abdominis (TrA) was evaluated by ultrasound imaging in these patients. Compared with the HCs, they displayed a significant decrease in GMV in the bilateral thalamus and caudate nucleus, a significant increase in GMV in the left middle frontal gyrus, and increased resting-state functional connectivity between the right caudate nucleus and the bilateral precuneus (voxel-level Grey matter alterations may be confined to regions responsible for perception, motor control, and emotion regulation in patients with CLBP. The interrupted EC from the basal ganglia to the default mode network might be involved in the impairment of voluntary activation of the core stabilizing muscles.
Identifiants
pubmed: 37693681
doi: 10.1155/2023/2028379
pmc: PMC10484657
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2028379Informations de copyright
Copyright © 2023 Chanjuan Zhang et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Références
Front Psychiatry. 2020 Apr 23;11:308
pubmed: 32390883
J Athl Train. 2018 Jun;53(6):553-559
pubmed: 29912568
Brain. 2008 Aug;131(Pt 8):2161-71
pubmed: 18669505
Eur Spine J. 2022 Jan;31(1):136-151
pubmed: 34553264
Eur Spine J. 2013 Sep;22(9):1958-64
pubmed: 23392554
Front Aging Neurosci. 2016 Jan 19;8:3
pubmed: 26834629
J Neurosci. 2003 Oct 8;23(27):9240-5
pubmed: 14534258
Neuroimage Clin. 2017 Oct 19;17:222-231
pubmed: 29159039
Neuroscientist. 2019 Dec;25(6):583-596
pubmed: 30387689
Pain. 2009 Apr;142(3):183-188
pubmed: 19186001
Front Mol Neurosci. 2022 Oct 19;15:1032617
pubmed: 36340685
Clin J Pain. 2015 Oct;31(10):893-902
pubmed: 25380224
Gait Posture. 2016 Sep;49:73-77
pubmed: 27388960
Psychosom Med. 2019 Feb/Mar;81(2):146-154
pubmed: 30615602
Brain Behav Immun. 2019 Nov;82:253-263
pubmed: 31472246
PM R. 2013 Aug;5(8):678-87
pubmed: 23507347
Front Psychiatry. 2022 Apr 15;13:809891
pubmed: 35492728
Childs Nerv Syst. 2002 Aug;18(8):386-404
pubmed: 12192499
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Br J Sports Med. 2010 Dec;44(16):1166-72
pubmed: 19474006
Neural Regen Res. 2013 Nov 15;8(32):2981-90
pubmed: 25206618
Neuroimage Clin. 2017 Jul 18;16:116-124
pubmed: 28794972
Brain Topogr. 2014 May;27(3):366-74
pubmed: 23636269
Neuroimage. 2013 Oct 15;80:246-62
pubmed: 23631983
Work. 2005;25(4):307-14
pubmed: 16340107
Brain Imaging Behav. 2022 Aug;16(4):1516-1527
pubmed: 35080703
Neuroscience. 2022 Apr 1;487:143-154
pubmed: 35134490
BMC Musculoskelet Disord. 2012 Sep 06;13:166
pubmed: 22950571
J Orthop Sports Phys Ther. 2014 Dec;44(12):979-88
pubmed: 25366083
Brain Imaging Behav. 2017 Apr;11(2):486-492
pubmed: 26899433
Braz J Phys Ther. 2021 Jan-Feb;25(1):86-96
pubmed: 32434666
Cir Cir. 2011 May-Jun;79(3):264-79, 286-302
pubmed: 22381000
Hum Brain Mapp. 2019 May;40(7):2017-2032
pubmed: 30318709
Front Neurosci. 2019 Sep 17;13:970
pubmed: 31607840
J Spinal Disord. 1992 Dec;5(4):383-9; discussion 397
pubmed: 1490034
Med Eng Phys. 2018 Oct;60:39-46
pubmed: 30077486
Pain. 2006 Nov;125(1-2):89-97
pubmed: 16750298
J Neurosci. 2004 Nov 17;24(46):10410-5
pubmed: 15548656
J Neurosci Res. 2022 Jul;100(7):1487-1505
pubmed: 35441738
Spine (Phila Pa 1976). 2006 May 1;31(10):1083-93
pubmed: 16648741
Ann Intern Med. 2017 Apr 4;166(7):514-530
pubmed: 28192789
Physiol Rev. 2020 Jan 1;100(1):271-320
pubmed: 31512990
Mol Pain. 2018 Jan-Dec;14:1744806918755283
pubmed: 29353539
Spine (Phila Pa 1976). 2017 May 15;42(10):726-732
pubmed: 27879564
J Orthop Sports Phys Ther. 2019 Jun;49(6):370-379
pubmed: 29895230
Lancet. 2018 Jun 9;391(10137):2356-2367
pubmed: 29573870
Pain Res Manag. 2020 Oct 28;2020:9629526
pubmed: 33193926
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Neurosci Biobehav Rev. 2020 Aug;115:351-362
pubmed: 32407735
N Engl J Med. 2022 May 5;386(18):1732-1740
pubmed: 35507483
Eur J Pain. 2020 May;24(5):945-955
pubmed: 32061140
Genes Brain Behav. 2017 Nov;16(8):781-789
pubmed: 28749606
Mol Pain. 2010 May 13;6:27
pubmed: 20465845
Health Qual Life Outcomes. 2017 Oct 3;15(1):192
pubmed: 28974227
Neurosci Bull. 2014 Dec;30(6):949-955
pubmed: 25098351
Eur J Phys Rehabil Med. 2021 Oct;57(5):793-806
pubmed: 33960180
PM R. 2018 May;10(5):483-493
pubmed: 29097271
Neuroimage Clin. 2019;24:101951
pubmed: 31374398
Neuromodulation. 2018 Jan;21(1):1-9
pubmed: 29230905
Expert Rev Neurother. 2020 Apr;20(4):401-412
pubmed: 32130037
J Anesth. 2018 Dec;32(6):831-843
pubmed: 30264383
Neuron. 2013 Aug 21;79(4):814-28
pubmed: 23972602
Orthop Traumatol Surg Res. 2019 Apr;105(2):339-346
pubmed: 30792166
Exp Brain Res. 2016 Apr;234(4):1033-45
pubmed: 26708518