CD4+ T-cell subsets in autoimmune hepatitis: A review.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
received:
20
07
2023
accepted:
02
08
2023
medline:
12
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis of AIH requires the identification of lymphoblast cell interface hepatitis and serum biochemical abnormalities, as well as the exclusion of related diseases. According to different specific autoantibodies, AIH can be divided into AIH-1 and AIH-2. The first-line treatment for AIH is a corticosteroid and azathioprine regimen, and patients with liver failure require liver transplantation. However, the long-term use of corticosteroids has obvious side effects, and patients are prone to relapse after drug withdrawal. Autoimmune diseases are characterized by an imbalance in immune tolerance of self-antigens, activation of autoreactive T cells, overactivity of B cells, and increased production of autoantibodies. CD4+ T cells are key players in adaptive immunity and can secrete cytokines, activate B cells to produce antibodies, and influence the cytotoxicity of CD8+ T cells. According to their characteristics, CD4+ T cells can be divided into different subsets. In this review, we discuss the changes in T helper (Th)1, Th2, Th17, Th9, Th22, regulatory T cell, T follicular helper, and T peripheral helper cells and their related factors in AIH and discuss the therapeutic potential of targeting CD4+ T-cell subsets in AIH.
Identifiants
pubmed: 37695088
doi: 10.1097/HC9.0000000000000269
pii: 02009842-202310010-00008
pmc: PMC10497257
pii:
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.
Références
Annu Rev Immunol. 1998;16:523-44
pubmed: 9597140
Immunity. 2016 Jan 19;44(1):131-142
pubmed: 26750311
Arthritis Rheumatol. 2017 Oct;69(10):2038-2051
pubmed: 28622456
Adv Exp Med Biol. 2016;941:31-77
pubmed: 27734408
Immunity. 2008 Jul 18;29(1):138-49
pubmed: 18599325
Adv Exp Med Biol. 2016;941:191-211
pubmed: 27734414
Immunity. 2021 Dec 14;54(12):2740-2755.e6
pubmed: 34644536
Immunity. 2016 Jun 21;44(6):1284-98
pubmed: 27332731
J Autoimmun. 2019 May;99:1-14
pubmed: 30773373
Front Immunol. 2019 Sep 27;10:2318
pubmed: 31611881
Immunol Rev. 2014 May;259(1):192-205
pubmed: 24712467
Clin Immunol. 2020 Sep;218:108515
pubmed: 32619646
Front Immunol. 2019 Feb 12;10:229
pubmed: 30809232
J Immunol. 2011 Jan 15;186(2):667-74
pubmed: 21169545
J Autoimmun. 2005 Dec;25(4):283-8
pubmed: 16242912
J Immunol. 2005 Jan 1;174(1):294-301
pubmed: 15611252
Int Immunopharmacol. 2014 May;20(1):248-57
pubmed: 24631515
J Int Med Res. 2020 Mar;48(3):300060519889441
pubmed: 31852338
J Autoimmun. 2021 Feb;117:102591
pubmed: 33387980
Immunity. 1998 Nov;9(5):745-55
pubmed: 9846495
J Autoimmun. 2021 May;119:102629
pubmed: 33721837
Int J Mol Sci. 2020 Jul 22;21(15):
pubmed: 32707869
J Immunol Res. 2018 Jun 27;2018:3753081
pubmed: 30050955
Cell Commun Signal. 2022 Jun 3;20(1):83
pubmed: 35658901
Turk J Gastroenterol. 2017 Mar;28(2):110-114
pubmed: 28119269
Semin Immunopathol. 2019 May;41(3):301-314
pubmed: 30953162
Adv Immunol. 2015;125:87-110
pubmed: 25591465
J Immunol. 2016 Sep 15;197(6):2145-56
pubmed: 27511737
Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(8):463-85
pubmed: 21986312
Nat Immunol. 2016 Dec;17(12):1447-1458
pubmed: 27798619
Science. 2003 Feb 14;299(5609):1057-61
pubmed: 12522256
Front Immunol. 2020 Oct 07;11:575572
pubmed: 33117375
Immunity. 2007 Oct;27(4):647-59
pubmed: 17919941
Cancers (Basel). 2018 Jun 11;10(6):
pubmed: 29891791
Exp Anim. 2023 Aug 7;72(3):367-378
pubmed: 36927981
Annu Rev Immunol. 2011;29:665-705
pubmed: 21219180
Immunity. 2003 Nov;19(5):739-48
pubmed: 14614860
Semin Arthritis Rheum. 2020 Oct;50(5):867-872
pubmed: 32896702
J Immunol. 2007 Oct 15;179(8):5099-108
pubmed: 17911595
Immunol Cell Biol. 2010 Mar-Apr;88(3):244-9
pubmed: 20065998
Ann Rheum Dis. 2019 Feb;78(2):209-217
pubmed: 30472651
Expert Rev Gastroenterol Hepatol. 2016;10(5):659-63
pubmed: 26735262
Gastroenterology. 2008 Dec;135(6):2107-18
pubmed: 18773898
J Hepatol. 2021 Jan;74(1):48-57
pubmed: 32663496
J Hepatol. 2004 Jul;41(1):31-7
pubmed: 15246204
Front Immunol. 2022 Feb 17;13:826732
pubmed: 35251009
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1605-1609
pubmed: 30072097
Front Immunol. 2022 Jun 03;13:899609
pubmed: 35720411
Immunol Rev. 2022 May;307(1):191-202
pubmed: 35103314
JCI Insight. 2017 May 4;2(9):
pubmed: 28469075
Immunobiology. 2022 Mar;227(2):152182
pubmed: 35134627
Egypt J Immunol. 2020 Jun;27(2):19-30
pubmed: 33548974
J Clin Invest. 2011 Nov;121(11):4503-15
pubmed: 21965331
Hum Immunol. 2017 Feb;78(2):120-128
pubmed: 28040536
Rheumatology (Oxford). 2022 Mar 2;61(3):1233-1242
pubmed: 34009274
J Inflamm Res. 2022 Mar 11;15:1797-1810
pubmed: 35300210
Life Sci. 2021 Jan 1;264:118677
pubmed: 33129875
Fac Rev. 2021 Mar 15;10:30
pubmed: 33817699
Gastroenterology. 2011 Apr;140(4):1322-1333.e1-5
pubmed: 21237169
Nat Commun. 2021 Feb 5;12(1):832
pubmed: 33547304
Mol Immunol. 2018 Jul;99:171-181
pubmed: 29793131
Rheumatology (Oxford). 2023 Jul 5;62(7):2464-2474
pubmed: 36370078
Front Immunol. 2022 Apr 25;13:810671
pubmed: 35547732
Int J Mol Sci. 2021 Dec 17;22(24):
pubmed: 34948375
Exp Mol Pathol. 2018 Dec;105(3):279-284
pubmed: 30291855
Front Immunol. 2021 Apr 16;12:654839
pubmed: 33936082
Elife. 2017 Jan 06;6:
pubmed: 28059703
Hepatology. 1996 Nov;24(5):1068-73
pubmed: 8903377
J Immunol. 2012 Apr 15;188(8):3734-44
pubmed: 22427637
J Immunol. 2019 Dec 15;203(12):3148-3156
pubmed: 31685647
J Hepatol. 2013 Mar;58(3):529-34
pubmed: 23178709
Cell. 2020 Oct 1;183(1):143-157.e13
pubmed: 32877699
Cell Mol Immunol. 2021 Jan;18(1):92-111
pubmed: 33110250
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):
pubmed: 34301886
Immunol Cell Biol. 2022 Jan;100(1):21-32
pubmed: 34219288
Autoimmunity. 2020 Feb;53(1):8-20
pubmed: 31771364
Hepatology. 2015 Sep;62(3):863-75
pubmed: 25953611
PLoS One. 2011 Mar 14;6(3):e17739
pubmed: 21423809
Nature. 2013 Apr 25;496(7446):523-7
pubmed: 23619696
J Immunother Cancer. 2021 Jul;9(7):
pubmed: 34253636
Nature. 2017 Feb 1;542(7639):110-114
pubmed: 28150777
Immunol Rev. 2016 May;271(1):141-55
pubmed: 27088912
Semin Immunopathol. 2021 Aug;43(4):549-561
pubmed: 34463867
Hepatology. 2020 Aug;72(2):671-722
pubmed: 31863477
Immunity. 2012 Nov 16;37(5):785-99
pubmed: 23123060
J Exp Med. 2016 Feb 8;213(2):251-71
pubmed: 26834156
Middle East J Dig Dis. 2019 Apr;11(2):98-103
pubmed: 31380006
J Cell Mol Med. 2021 Jul;25(14):6746-6759
pubmed: 34132026
Cytokine. 2015 Jul;74(1):5-17
pubmed: 25458968
Front Immunol. 2019 Oct 18;10:2486
pubmed: 31681337
Nature. 2003 Jan 16;421(6920):282-7
pubmed: 12529646
Immunol Rev. 2014 May;259(1):88-102
pubmed: 24712461
Mol Cell Proteomics. 2012 Dec;11(12):1885-97
pubmed: 22997428
Exp Ther Med. 2019 Dec;18(6):4845-4851
pubmed: 31772648
Immunity. 2022 Apr 12;55(4):639-655.e7
pubmed: 35381213
Nat Rev Immunol. 2010 Nov;10(11):753-66
pubmed: 20972472
Haematologica. 2010 Mar;95(3):432-9
pubmed: 20207847
World J Gastroenterol. 2017 Sep 7;23(33):6030-6048
pubmed: 28970719
Nat Commun. 2020 Sep 28;11(1):4882
pubmed: 32985505
Cancer Treat Rev. 2018 Feb;63:40-47
pubmed: 29207310
Science. 2017 Mar 31;355(6332):1428-1433
pubmed: 28280247
Cell Mol Immunol. 2004 Feb;1(1):43-9
pubmed: 16212920
Cell Immunol. 2022 Aug;378:104575
pubmed: 35779312
Clin Immunol. 2013 Jan;146(1):15-25
pubmed: 23178752
J Immunol. 2020 Oct 1;205(7):1721-1730
pubmed: 32958706
Cardiovasc Res. 2018 Jan 1;114(1):180-187
pubmed: 29036304
Springerplus. 2016 Jun 18;5(1):777
pubmed: 27386263
Turk J Gastroenterol. 2017 Mar;28(2):115-116
pubmed: 28346187
Oncotarget. 2017 Apr 27;8(37):60933-60940
pubmed: 28977835
Front Cell Infect Microbiol. 2022 Oct 13;12:994838
pubmed: 36310865
J Immunol. 2005 Mar 1;174(5):2720-9
pubmed: 15728480
Hepatology. 2018 Oct;68(4):1649-1652
pubmed: 29698571
Immunity. 2013 Oct 17;39(4):770-81
pubmed: 24138884
Nat Commun. 2017 May 12;8:15366
pubmed: 28497800
Nat Commun. 2016 Feb 26;7:10875
pubmed: 26915335
Cell. 2015 Dec 3;163(6):1400-12
pubmed: 26607794
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):472-480
pubmed: 28802860
United European Gastroenterol J. 2019 Nov;7(9):1156-1163
pubmed: 31700628
Arthritis Res Ther. 2020 Sep 23;22(1):222
pubmed: 32972460
Front Med (Lausanne). 2021 Aug 09;8:708140
pubmed: 34434945
Cold Spring Harb Perspect Biol. 2019 Feb 1;11(2):
pubmed: 29038121
Curr Allergy Asthma Rep. 2019 Mar 26;19(5):29
pubmed: 30915580
Nat Immunol. 2009 Aug;10(8):864-71
pubmed: 19578368
Sci Rep. 2016 Jan 05;6:18694
pubmed: 26728971
J Gastroenterol Hepatol. 2018 Jan;33(1):298-306
pubmed: 28591933
J Hepatol. 2020 Dec;73(6):1379-1390
pubmed: 32649971
J Leukoc Biol. 2010 Apr;87(4):703-12
pubmed: 20042469
J Immunol. 2010 Jul 1;185(1):313-26
pubmed: 20519643
FEBS Open Bio. 2021 May;11(5):1406-1416
pubmed: 33728805
Braz J Med Biol Res. 2022 Dec 02;55:e12002
pubmed: 36477951
FEBS Open Bio. 2021 Feb;11(2):395-403
pubmed: 33249782
Cell. 2015 Dec 3;163(6):1413-27
pubmed: 26607793
J Mol Histol. 2022 Apr;53(2):413-421
pubmed: 35064420
Hepatol Res. 2019 Sep;49(9):1026-1033
pubmed: 31020718
Bull Exp Biol Med. 2015 Dec;160(2):252-5
pubmed: 26631389
Biomed Pharmacother. 2020 Sep;129:110396
pubmed: 32580046
Cells. 2021 Nov 03;10(11):
pubmed: 34831223
Front Immunol. 2021 Jul 06;12:688066
pubmed: 34295334
Cell Mol Immunol. 2021 May;18(5):1329-1331
pubmed: 32636527
Curr Opin Immunol. 2014 Jun;28:34-41
pubmed: 24583637
Front Immunol. 2023 Jan 04;13:1081153
pubmed: 36685550
Int J Endocrinol. 2020 Feb 17;2020:6543593
pubmed: 32351559
Int J Mol Sci. 2020 Dec 23;22(1):
pubmed: 33374787
J Exp Med. 2015 Feb 9;212(2):217-33
pubmed: 25646266
J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5):1719-1727
pubmed: 33179463
Gastroenterology. 2006 Mar;130(3):868-82
pubmed: 16530525
Comb Chem High Throughput Screen. 2019;22(4):232-237
pubmed: 30947662
Front Immunol. 2019 Apr 03;10:642
pubmed: 31001262
Front Immunol. 2016 Nov 23;7:520
pubmed: 27933060
J Exp Med. 2020 Feb 13;217(3):e20192195
pubmed: 32997932
J Immunol. 2017 Mar 1;198(5):2182-2190
pubmed: 28100680
Nature. 2007 Feb 15;445(7129):771-5
pubmed: 17220874
Immunity. 2009 Sep 18;31(3):457-68
pubmed: 19631565
Arthritis Res Ther. 2022 May 23;24(1):121
pubmed: 35606782
Annu Rev Immunol. 2023 Apr 26;41:483-512
pubmed: 36750317
J Biol Chem. 2015 Aug 7;290(32):19458-68
pubmed: 26109067
J Exp Med. 2005 Sep 19;202(6):793-804
pubmed: 16172258
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2319-23
pubmed: 24966942
Nat Rev Dis Primers. 2018 Apr 12;4:18018
pubmed: 29644995
J Biol Chem. 2008 May 30;283(22):14955-62
pubmed: 18400747
Blood. 2020 Feb 20;135(8):568-581
pubmed: 31880771
Methods Mol Biol. 2022;2380:59-76
pubmed: 34802122
Pediatr Int. 2008 Jun;50(3):284-6
pubmed: 18533937
J Exp Clin Cancer Res. 2022 May 5;41(1):166
pubmed: 35513871
J Immunol. 2009 Feb 15;182(4):1781-7
pubmed: 19201828
Eur Cytokine Netw. 2020 Dec 3;:
pubmed: 33270020
Hum Vaccin Immunother. 2020 Oct 2;16(10):2333-2340
pubmed: 32040369
JCI Insight. 2019 Oct 17;4(20):
pubmed: 31536480
Front Immunol. 2021 Jun 18;12:685400
pubmed: 34354706
Phytomedicine. 2021 Apr;84:153519
pubmed: 33640781
Nat Immunol. 2010 Feb;11(2):114-20
pubmed: 20084069
Nucleic Acids Res. 2022 May 6;50(8):4557-4573
pubmed: 35438764
Int J Mol Sci. 2019 Jul 10;20(14):
pubmed: 31295952
Int J Mol Med. 2018 Mar;41(3):1518-1528
pubmed: 29286082
J Infect. 2018 Apr;76(4):406-416
pubmed: 29391143
Immunity. 2014 Mar 20;40(3):367-77
pubmed: 24631156
Front Immunol. 2018 Aug 23;9:1924
pubmed: 30190721
J Immunol. 2016 Apr 15;196(8):3297-304
pubmed: 26976954
J Exp Med. 2006 Jun 12;203(6):1551-65
pubmed: 16754717
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):524-9
pubmed: 25548162
Eur J Immunol. 2010 Jul;40(7):1830-5
pubmed: 20583029
J Autoimmun. 2021 May;119:102619
pubmed: 33652348
Biochem Biophys Rep. 2020 Sep 10;24:100803
pubmed: 32984557
Dig Dis Sci. 2022 Nov;67(11):4979-5005
pubmed: 35147819
Curr Allergy Asthma Rep. 2016 Jun;16(6):45
pubmed: 27221343
Nat Neurosci. 2019 May;22(5):729-740
pubmed: 30962630
J Exp Med. 2017 Nov 6;214(11):3381-3398
pubmed: 29018045
J Exp Med. 2012 Oct 22;209(11):2079-97
pubmed: 23027924
Curr Opin Rheumatol. 2017 Jul;29(4):361-368
pubmed: 28362657
J Immunol. 2012 Jun 1;188(11):5776-84
pubmed: 22547695
Cell Immunol. 2022 May;375:104517
pubmed: 35398604
Clin Gastroenterol Hepatol. 2015 Mar;13(3):602-8
pubmed: 25131534
Cell. 2000 Mar 17;100(6):655-69
pubmed: 10761931
Cell Biochem Funct. 2020 Jun;38(4):480-489
pubmed: 31989663
J Hepatol. 2012 Jul;57(1):125-32
pubmed: 22425700
Trends Immunol. 2021 Aug;42(8):658-669
pubmed: 34244056
Immunol Cell Biol. 2010 Mar-Apr;88(3):236-9
pubmed: 20157328
J Immunol. 2006 Apr 1;176(7):4484-91
pubmed: 16547287
Hepatology. 2009 Jul;50(1):130-42
pubmed: 19437492
Front Immunol. 2023 Apr 03;14:1145573
pubmed: 37077922
Front Immunol. 2022 May 19;13:880262
pubmed: 35663990
PLoS One. 2017 Jul 11;12(7):e0181107
pubmed: 28700730
PLoS One. 2011 Apr 19;6(4):e18909
pubmed: 21526159
Cell Death Differ. 2017 Jun;24(6):997-1006
pubmed: 28304404
Adv Immunol. 2019;144:155-171
pubmed: 31699216
Immunity. 2009 Jul 17;31(1):158-69
pubmed: 19592276
Middle East J Dig Dis. 2018 Apr;10(2):105-108
pubmed: 30013759
Front Immunol. 2021 Apr 12;12:626172
pubmed: 33912156
Semin Immunopathol. 2017 Jan;39(1):79-87
pubmed: 27844107
J Autoimmun. 2016 Aug;72:102-12
pubmed: 27210814
Mol Immunol. 2022 Apr;144:127-137
pubmed: 35219910
Trends Immunol. 2017 Nov;38(11):805-816
pubmed: 28830733
Nat Commun. 2017 May 30;8:15628
pubmed: 28555647
J Immunol. 2013 Sep 1;191(5):2360-71
pubmed: 23913959
Liver Int. 2014 Mar;34(3):405-15
pubmed: 23826746
Clin Exp Immunol. 2020 Mar;199(3):255-262
pubmed: 31386175
Parasite Immunol. 2017 Oct;39(10):
pubmed: 28748530
Semin Immunopathol. 2019 May;41(3):283-297
pubmed: 30891627
Annu Rev Immunol. 2008;26:57-79
pubmed: 17953510
Cytokine. 2022 Jan;149:155749
pubmed: 34739898
Nat Immunol. 2017 Jun 20;18(7):716-724
pubmed: 28632714
Eur J Immunol. 2018 Apr;48(4):705-715
pubmed: 29349774
Immunology. 2020 May;160(1):24-37
pubmed: 32022254
Arthritis Rheumatol. 2021 Jan;73(1):132-142
pubmed: 32720470
Annu Rev Immunol. 2010;28:445-89
pubmed: 20192806
Int Immunol. 2013 Oct;25(10):547-51
pubmed: 24027199
J Autoimmun. 2005 Aug;25(1):63-71
pubmed: 16005184
Nat Commun. 2016 Jan 08;7:10285
pubmed: 26743592
Trends Immunol. 2012 Jun;33(6):256-63
pubmed: 22591984
Pol Arch Intern Med. 2018 Mar 29;128(3):150-156
pubmed: 29363666
Nature. 2012 Apr 26;484(7395):514-8
pubmed: 22466287
Nat Immunol. 2016 Aug;17(8):976-84
pubmed: 27376469
J Autoimmun. 2013 Mar;41:146-51
pubmed: 23287048
Front Immunol. 2022 Sep 29;13:1025343
pubmed: 36248826
Immunity. 2000 Jan;12(1):27-37
pubmed: 10661403
Nat Immunol. 2004 Nov;5(11):1157-65
pubmed: 15475959
J Immunol. 2020 Mar 1;204(5):1201-1213
pubmed: 31932499
J Hepatol. 2014 Nov;61(5):1106-14
pubmed: 24882050
Hepatology. 2012 Aug;56(2):677-86
pubmed: 22371007
Int J Biol Sci. 2020 Jun 29;16(13):2405-2413
pubmed: 32760208