Accumulation of advanced glycation end products promotes atrophic nonunion incidence in mice through a CtBP1/2-dependent mechanism.

Mice Animals Core Binding Factor Alpha 1 Subunit Incidence Transcription Factors Glycation End Products, Advanced Receptor for Advanced Glycation End Products
Advanced glycation end products Atrophic nonunion C-terminal binding protein Histone deacetylase 1 Runt-related transcription factor 2

Journal

Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226

Informations de publication

Date de publication:
01 11 2023
Historique:
received: 22 06 2023
revised: 13 08 2023
accepted: 01 09 2023
medline: 2 10 2023
pubmed: 12 9 2023
entrez: 11 9 2023
Statut: ppublish

Résumé

Atrophic nonunion (AN) is a complex and poorly understood pathological condition resulting from impaired fracture healing. Advanced glycation end products (AGEs) have been implicated in the pathogenesis of several bone disorders, including osteoporosis and osteoarthritis. However, the role of AGEs in the development of AN remains unclear. This study found that mice fed a high-AGE diet had a higher incidence of atrophic nonunion (AN) compared to mice fed a normal diet following tibial fractures. AGEs induced two C-terminal binding proteins (CtBPs), CtBP1 and CtBP2, which were necessary for the development of AN in response to AGE accumulation. Feeding a high-AGE diet after fracture surgery in CtBP1/2

Identifiants

DOI: 10.1016/j.yexcr.2023.113765 PMID: 37696386
pubmed: 37696386
pii: S0014-4827(23)00313-0
doi: 10.1016/j.yexcr.2023.113765
pii:
doi:

Substances chimiques

Core Binding Factor Alpha 1 Subunit 0
Transcription Factors 0
Glycation End Products, Advanced 0
Receptor for Advanced Glycation End Products 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113765

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no any financial or nonfinancial interests that might have influenced the performance or presentation of the work described in this manuscript.

Auteurs

Xun Chen (X)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Chaofeng Wang (C)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Dawei Zhou (D)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Guolong Zhao (G)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Zhong Li (Z)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Ning Duan (N)

Department of Orthopaedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China. Electronic address: duanning2008@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Accumulation of advanced glycation end...
questionsmedicales.fr › Eucaryotes › Animaux › Accumulation of advanced glycation end...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBF › Sous-unités alpha du facteur CBF › Sous-unité alpha 1 du facteur CBF › Accumulation of advanced glycation end...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Accumulation of advanced glycation end...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Accumulation of advanced glycation end...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Accumulation of advanced glycation end...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Récepteur spécifique des produits finaux de glycosylation avancée › Accumulation of advanced glycation end...