Structure of a fungal 1,3-β-glucan synthase.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
15 09 2023
15 09 2023
Historique:
medline:
15
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
ppublish
Résumé
1,3-β-Glucan serves as the primary component of the fungal cell wall and is produced by 1,3-β-glucan synthase located in the plasma membrane. This synthase is a molecular target for antifungal drugs such as echinocandins and the triterpenoid ibrexafungerp. In this study, we present the cryo-electron microscopy structure of
Identifiants
pubmed: 37703377
doi: 10.1126/sciadv.adh7820
pmc: PMC10499315
doi:
Substances chimiques
beta-Glucans
0
1,3-beta-glucan synthase
EC 2.4.1.34
Antifungal Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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