AXL receptor tyrosine kinase inhibition improves the anti-tumor effects of CD8

Mice Animals CD8-Positive T-Lymphocytes Axl Receptor Tyrosine Kinase Neoplasms / drug therapy Dendritic Cells Tumor Microenvironment Mice, Inbred C57BL
AXL receptor tyrosine kinase (AXL) CD8(+) T cell Dendritic cell (DC) Lung cancer Tumor microenvironment

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
05 11 2023
Historique:
received: 10 08 2023
revised: 23 08 2023
accepted: 10 09 2023
medline: 10 10 2023
pubmed: 13 9 2023
entrez: 13 9 2023
Statut: ppublish

Résumé

AXL is a member of TAM receptor family and has been highlighted as a potential target for cancer treatment. Accumulating evidence has uncovered the critical role of the AXL signaling pathway in tumor growth, metastasis, and resistance against anti-cancer drugs, as well as its association with cancer immune escape. However, the function of AXL as a manipulator of the immune system in the tumor microenvironment (TME) remains unclear. Therefore, in this study, we investigated the impact of AXL on immune cells in the TME of a syngeneic tumor model using AXL knockout (AXL

Identifiants

DOI: 10.1016/j.bbrc.2023.09.021 PMID: 37703603
pubmed: 37703603
pii: S0006-291X(23)01051-3
doi: 10.1016/j.bbrc.2023.09.021
pii:
doi:

Substances chimiques

Axl Receptor Tyrosine Kinase 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7-14

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kyungtaek Im (K)

Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Yun Jung Choi (YJ)

Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Dong Ha Kim (DH)

Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Da-Som Kim (DS)

Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Kyosun Ban (K)

Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Wonjun Ji (W)

Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

In-Jeoung Baek (IJ)

Department of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Chang-Min Choi (CM)

Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Jae Cheol Lee (JC)

Department of Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea.

Jin Kyung Rho (JK)

Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, 05505, South Korea. Electronic address: jkrho@amc.seoul.kr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Axl Receptor Tyrosine Kinase › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Tumeurs › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › AXL receptor tyrosine kinase inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › AXL receptor tyrosine kinase inhibition...