HMGB2 regulates the differentiation and stemness of exhausted CD8

Humans CD8-Positive T-Lymphocytes HMGB2 Protein / genetics Persistent Infection Cell Differentiation Virus Diseases Neoplasms

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
13 09 2023
Historique:
received: 20 06 2022
accepted: 31 08 2023
medline: 15 9 2023
pubmed: 14 9 2023
entrez: 13 9 2023
Statut: epublish

Résumé

Chronic infections and cancers evade the host immune system through mechanisms that induce T cell exhaustion. The heterogeneity within the exhausted CD8

Identifiants

DOI: 10.1038/s41467-023-41352-0 PMID: 37704621 PMC: PMC10499904
pubmed: 37704621
doi: 10.1038/s41467-023-41352-0
pii: 10.1038/s41467-023-41352-0
pmc: PMC10499904
doi:

Substances chimiques

HMGB2 Protein 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5631

Subventions

Organisme : NCI NIH HHS
ID : P30 CA062203
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137239
Pays : United States

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Emily N Neubert (EN)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.
Center for Virus Research, University of California Irvine, Irvine, CA, 92697, USA.

Julia M DeRogatis (JM)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.

Sloan A Lewis (SA)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.
La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.

Karla M Viramontes (KM)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.

Pedro Ortega (P)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA.
ORCID: 0000-0003-4216-3695

Monique L Henriquez (ML)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.
ORCID: 0000-0001-5684-5959

Rémi Buisson (R)

Center for Virus Research, University of California Irvine, Irvine, CA, 92697, USA.
Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA.
ORCID: 0000-0002-7196-8209

Ilhem Messaoudi (I)

Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, 40536, USA.
ORCID: 0000-0003-3203-2405

Roberto Tinoco (R)

Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA. rtinoco@uci.edu.
Center for Virus Research, University of California Irvine, Irvine, CA, 92697, USA. rtinoco@uci.edu.
Institute for Immunology, University of California, Irvine, Irvine, CA, 92697, USA. rtinoco@uci.edu.
Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, 92697, USA. rtinoco@uci.edu.
ORCID: 0000-0001-5420-9692

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › HMGB2 regulates the differentiation and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › HMGB2 regulates the differentiation and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Protéines HMG › Protéines HMGB › Protéine HMG2 › HMGB2 regulates the differentiation and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Infection persistante › HMGB2 regulates the differentiation and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › HMGB2 regulates the differentiation and...
questionsmedicales.fr › Infection › Maladies virales › HMGB2 regulates the differentiation and...
questionsmedicales.fr › Tumeurs › HMGB2 regulates the differentiation and...