Association of Baseline Cerebrovascular Reactivity and Longitudinal Development of Enlarged Perivascular Spaces in the Basal Ganglia.
carbon dioxide
cerebral small vessel disease
executive function
hypercapnia
magnetic resonance imaging
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
pmc-release:
01
11
2024
medline:
1
11
2023
pubmed:
15
9
2023
entrez:
15
9
2023
Statut:
ppublish
Résumé
Increasing evidence suggests that enlarged perivascular spaces (ePVS) are associated with cognitive dysfunction in aging. However, the pathogenesis of ePVS remains unknown. Here, we tested the possibility that baseline cerebrovascular dysfunction, as measured by a magnetic resonance imaging measure of cerebrovascular reactivity, contributes to the later development of ePVS. Fifty cognitively unimpaired, older adults (31 women; age range, 60-84 years) underwent magnetic resonance imaging scanning at baseline and follow-up separated by ≈2.5 years. ePVS were counted in the basal ganglia, centrum semiovale, midbrain, and hippocampus. Cerebrovascular reactivity, an index of the vasodilatory capacity of cerebral small vessels, was assessed using carbon dioxide inhalation while acquiring blood oxygen level-dependent magnetic resonance images. Low baseline cerebrovascular reactivity values in the basal ganglia were associated with increased follow-up ePVS counts in the basal ganglia after controlling for age, sex, and baseline ePVS values (estimate [SE]=-3.18 [0.96]; Our results demonstrate that low baseline cerebrovascular reactivity is a risk factor for later development of ePVS.
Sections du résumé
BACKGROUND
BACKGROUND
Increasing evidence suggests that enlarged perivascular spaces (ePVS) are associated with cognitive dysfunction in aging. However, the pathogenesis of ePVS remains unknown. Here, we tested the possibility that baseline cerebrovascular dysfunction, as measured by a magnetic resonance imaging measure of cerebrovascular reactivity, contributes to the later development of ePVS.
METHODS
METHODS
Fifty cognitively unimpaired, older adults (31 women; age range, 60-84 years) underwent magnetic resonance imaging scanning at baseline and follow-up separated by ≈2.5 years. ePVS were counted in the basal ganglia, centrum semiovale, midbrain, and hippocampus. Cerebrovascular reactivity, an index of the vasodilatory capacity of cerebral small vessels, was assessed using carbon dioxide inhalation while acquiring blood oxygen level-dependent magnetic resonance images.
RESULTS
RESULTS
Low baseline cerebrovascular reactivity values in the basal ganglia were associated with increased follow-up ePVS counts in the basal ganglia after controlling for age, sex, and baseline ePVS values (estimate [SE]=-3.18 [0.96];
CONCLUSIONS
CONCLUSIONS
Our results demonstrate that low baseline cerebrovascular reactivity is a risk factor for later development of ePVS.
Identifiants
pubmed: 37712232
doi: 10.1161/STROKEAHA.123.043882
pmc: PMC10615859
mid: NIHMS1927991
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2785-2793Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB031771
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS122028
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072946
Pays : United States
Organisme : NIA NIH HHS
ID : F30 AG079506
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068055
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055449
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028383
Pays : United States
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