Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins.
Journal
The CRISPR journal
ISSN: 2573-1602
Titre abrégé: CRISPR J
Pays: United States
ID NLM: 101738191
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
23
10
2023
pubmed:
15
9
2023
entrez:
15
9
2023
Statut:
ppublish
Résumé
Cas9 targets genomic loci with high specificity. For knockin with double-strand break repair, however, Cas9 often leads to unintended on-target knockout rather than intended edits. This imprecision is a barrier for direct
Identifiants
pubmed: 37713292
doi: 10.1089/crispr.2023.0036
pmc: PMC10611978
doi:
Substances chimiques
CRISPR-Associated Protein 9
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-461Références
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