Total synthesis of complex 2,5-diketopiperazine alkaloids.
Alkaloid
Cyclodipeptide
Diketopiperazine
Natural product
Synthesis
Journal
The Alkaloids. Chemistry and biology
ISSN: 1099-4831
Titre abrégé: Alkaloids Chem Biol
Pays: United States
ID NLM: 9812842
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
18
9
2023
pubmed:
17
9
2023
entrez:
16
9
2023
Statut:
ppublish
Résumé
The 2,5-diketopiperazine (DKP) motif is present in many biologically relevant, complex natural products. The cyclodipeptide substructure offers structural rigidity and stability to proteolysis that makes these compounds promising candidates for medical applications. Due to their fascinating molecular architecture, synthetic organic chemists have focused significant effort on the total synthesis of these compounds. This review covers many such efforts on the total synthesis of DKP containing complex alkaloid natural products.
Identifiants
pubmed: 37716796
pii: S1099-4831(23)00016-0
doi: 10.1016/bs.alkal.2023.06.002
pii:
doi:
Substances chimiques
2,5-dioxopiperazine
240L69DTV7
Diketopiperazines
0
Alkaloids
0
Biological Products
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-206Informations de copyright
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