Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
10
02
2023
revised:
20
07
2023
accepted:
08
08
2023
pmc-release:
01
12
2024
medline:
20
11
2023
pubmed:
18
9
2023
entrez:
17
9
2023
Statut:
ppublish
Résumé
Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled receptor called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lacked GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associated with a decline in Mac2
Identifiants
pubmed: 37717941
pii: S0002-9440(23)00322-X
doi: 10.1016/j.ajpath.2023.08.011
pmc: PMC10699127
pii:
doi:
Substances chimiques
resolvin D2
0
Receptors, G-Protein-Coupled
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1953-1968Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131842
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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