Sex and dose rate effects in automated cytogenetics.
Journal
Radiation protection dosimetry
ISSN: 1742-3406
Titre abrégé: Radiat Prot Dosimetry
Pays: England
ID NLM: 8109958
Informations de publication
Date de publication:
18 Sep 2023
18 Sep 2023
Historique:
received:
29
06
2022
revised:
17
10
2022
accepted:
16
11
2022
pmc-release:
18
09
2024
medline:
19
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Testing and validation of biodosimetry assays is routinely performed using conventional dose rate irradiation platforms, at a dose rate of approximately 1 Gy/min. In contrast, the exposures from an improvised nuclear device will be delivered over a large range of dose rates with a prompt irradiation component, delivered in less than 1 μs, and a protracted component delivered over hours and days. We present preliminary data from a large demographic study we have undertaken for investigation of age, sex and dose rate effects on dicentric and micronucleus yields. Our data demonstrate reduced dicentric and micronucleus yields at very high dose rates. Additionally, we have seen small differences between males and females, with males having slightly fewer micronuclei and slightly more dicentrics than females, at high doses.
Identifiants
pubmed: 37721073
pii: 7274411
doi: 10.1093/rpd/ncac286
pmc: PMC10505938
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1495-1500Subventions
Organisme : NIAID NIH HHS
ID : U19 AI067773
Pays : United States
Organisme : NIH HHS
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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