Frequency-Dependent Reduction of Cybersickness in Virtual Reality by Transcranial Oscillatory Stimulation of the Vestibular Cortex.

Humans Nausea Physical Therapy Modalities Transcranial Direct Current Stimulation Vestibular System Virtual Reality Double-Blind Method
Cybersickness Neuromodulation Transcranial alternating current stimulation Vestibular system Virtual reality

Journal

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381

Informations de publication

Date de publication:
Oct 2023
Historique:
accepted: 04 09 2023
medline: 30 11 2023
pubmed: 18 9 2023
entrez: 18 9 2023
Statut: ppublish

Résumé

Virtual reality (VR) applications are pervasive of everyday life, as in working, medical, and entertainment scenarios. There is yet no solution to cybersickness (CS), a disabling vestibular syndrome with nausea, dizziness, and general discomfort that most of VR users undergo, which results from an integration mismatch among visual, proprioceptive, and vestibular information. In a double-blind, controlled trial, we propose an innovative treatment for CS, consisting of online oscillatory imperceptible neuromodulation with transcranial alternating current stimulation (tACS) at 10 Hz, biophysically modelled to reach the vestibular cortex bilaterally. tACS significantly reduced CS nausea in 37 healthy subjects during a VR rollercoaster experience. The effect was frequency-dependent and placebo-insensitive. Subjective benefits were paralleled by galvanic skin response modulation in 25 subjects, addressing neurovegetative activity. Besides confirming the role of transcranially delivered oscillations in physiologically tuning the vestibular system function (and dysfunction), results open a new way to facilitate the use of VR in different scenarios and possibly to help treating also other vestibular dysfunctions.

Identifiants

DOI: 10.1007/s13311-023-01437-6 PMID: 37721646 PMC: PMC10684476
pubmed: 37721646
doi: 10.1007/s13311-023-01437-6
pii: 10.1007/s13311-023-01437-6
pmc: PMC10684476
doi:

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1796-1807

Subventions

Organisme : Horizon 2020 Framework Programme
ID : 101017727

Informations de copyright

© 2023. The Author(s).

Références

Cogn Behav Neurol. 2020 Jun;33(2):145-153
pubmed: 32496300
Hum Brain Mapp. 2013 Apr;34(4):923-35
pubmed: 22109746
Eur Arch Psychiatry Clin Neurosci. 2021 Feb;271(1):135-156
pubmed: 33211157
Clin Neurophysiol. 2017 Sep;128(9):1774-1809
pubmed: 28709880
Exp Brain Res. 2020 Oct;238(10):2347-2358
pubmed: 32757060
Cyberpsychol Behav Soc Netw. 2018 Jun;21(6):381-387
pubmed: 29792509
Clin Neurophysiol. 2023 Sep;153:123-132
pubmed: 37481873
Neurosci Lett. 2020 Aug 10;733:134974
pubmed: 32294492
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Physiol Behav. 2012 May 15;106(2):298-304
pubmed: 22330325
Nat Neurosci. 2018 Feb;21(2):174-187
pubmed: 29311747
Neurophysiol Clin. 2017 Apr;47(2):173-184
pubmed: 28410876
Brain Stimul. 2020 Sep - Oct;13(5):1254-1262
pubmed: 32534253
J Physiol Sci. 2020 Mar 14;70(1):17
pubmed: 32169037
Exp Brain Res. 2012 Jun;219(4):441-6
pubmed: 22526950
Methods Inf Med. 2003;42(5):524-34
pubmed: 14654887
Int J Neuropsychopharmacol. 2011 Sep;14(8):1133-45
pubmed: 21320389
Neurosci Biobehav Rev. 2020 Dec;119:294-319
pubmed: 32937115
Appl Psychophysiol Biofeedback. 2014 Dec;39(3-4):269-77
pubmed: 25280524
Handb Clin Neurol. 2016;137:371-90
pubmed: 27638085
Neuroimage. 2005 Jul 1;26(3):721-32
pubmed: 15955481
Brain Connect. 2018 May;8(4):235-244
pubmed: 29571264
JAMA Neurol. 2020 Feb 1;77(2):157-158
pubmed: 31764952
Appl Ergon. 2016 Mar;53 Pt B:374-82
pubmed: 26446454
Cureus. 2021 Jul 30;13(7):e16763
pubmed: 34367835
Front Neurol. 2019 Apr 24;10:377
pubmed: 31068887
Neuroimage. 2019 Dec;203:116183
pubmed: 31525498
Psychol Med. 2017 Oct;47(14):2393-2400
pubmed: 28325167
Nat Commun. 2019 Jun 12;10(1):2573
pubmed: 31189931
Percept Mot Skills. 2003 Dec;97(3 Pt 2):1051-7
pubmed: 15002846
Front Hum Neurosci. 2021 Oct 29;15:757735
pubmed: 34776909
Auton Neurosci. 2017 Mar;203:41-50
pubmed: 28010995
J Neurophysiol. 2016 Mar;115(3):1228-42
pubmed: 26683063
J Audiol Otol. 2022 Apr;26(2):76-82
pubmed: 35196446
J Educ Eval Health Prof. 2021;18:32
pubmed: 34897242
Clin Neurophysiol. 2021 Jan;132(1):269-306
pubmed: 33243615
PLoS One. 2022 Feb 4;17(2):e0263558
pubmed: 35120184
EXCLI J. 2022 May 31;21:791-792
pubmed: 35949490
Cogn Neuropsychol. 2020 Oct - Dec;37(7-8):413-420
pubmed: 32192411
Virtual Real. 2022;26(4):1347-1371
pubmed: 35250349
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:222-5
pubmed: 26736240

Auteurs

Alberto Benelli (A)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Francesco Neri (F)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Oto-Neuro-Tech Conjoined Lab, Policlinico Le Scotte, University of Siena, Siena, Italy.

Alessandra Cinti (A)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Patrizio Pasqualetti (P)

Health Statistics, University La Sapienza, Roma, Italy.

Sara M Romanella (SM)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Alessandro Giannotta (A)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

David De Monte (D)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Marco Mandalà (M)

Oto-Neuro-Tech Conjoined Lab, Policlinico Le Scotte, University of Siena, Siena, Italy.
Otolaryngology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Carmelo Smeralda (C)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Domenico Prattichizzo (D)

Oto-Neuro-Tech Conjoined Lab, Policlinico Le Scotte, University of Siena, Siena, Italy.
Siena Robotics and Systems (SiRS) Lab, Department of Information Engineering and Mathematics, University of Siena, Siena, Italy.

Emiliano Santarnecchi (E)

Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ESANTARNECCHI@mgh.harvard.edu.

Simone Rossi (S)

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Unit of Neurology and Clinical Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. rossisimo@unisi.it.
Oto-Neuro-Tech Conjoined Lab, Policlinico Le Scotte, University of Siena, Siena, Italy. rossisimo@unisi.it.
ORCID: 0000-0001-6697-9459

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Nausée › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › Thérapeutique › Techniques de physiothérapie › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › Disciplines et activités comportementales › Techniques psychologiques › Électrochoc › Stimulation transcrânienne par courant continu › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › Organes des sens › Système vestibulaire › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › Sciences de l'information › Affichage de données › Réalité de synthèse › Frequency-Dependent Reduction of Cybersickness...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en double aveugle › Frequency-Dependent Reduction of Cybersickness...