Biological variation in thyroid function tests in older adults and clinical implications.
biological variation
coefficient of variation
intraindividual variation
older adults
thyroid function
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
14
08
2023
received:
04
06
2023
accepted:
07
09
2023
medline:
6
11
2023
pubmed:
19
9
2023
entrez:
19
9
2023
Statut:
ppublish
Résumé
Interpreting thyroid function tests can be challenging due to inherent variation, and the need for tests rises with age. While age-related changes in thyrotropin (TSH) levels are known, the biological variation in older adults remains unclear. We recruited nineteen 65-99-year-old (older adults) without thyroid disease for monthly blood sampling for 1 year. Serum was stored at -20C°, and TSH, total thyroxine (TT4) and total triiodothyronine (TT3) were analysed in random order in a single batch for each participant. Results were compared to test results from 15 euthyroid men aged 24-53 years (younger adults) collected previously using a similar methodology. Interindividual coefficients of variation in older/younger adults were 46.7%/44.0% for TSH, 12.7%/19.5% for TT4 and 14.6%/22.4% for TT3. Intraindividual coefficients of variation (CV CV
Substances chimiques
Thyroxine
Q51BO43MG4
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
598-605Informations de copyright
© 2023 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
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