Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing.

Humans Mice Animals Epitopes, T-Lymphocyte CD8-Positive T-Lymphocytes Mice, Transgenic SARS-CoV-2 / metabolism CD4-Positive T-Lymphocytes
Animal testing HLA SARS-CoV-2 T cells Vaccine

Journal

Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872

Informations de publication

Date de publication:
11 2023
Historique:
received: 06 07 2023
accepted: 28 08 2023
medline: 1 11 2023
pubmed: 20 9 2023
entrez: 19 9 2023
Statut: ppublish

Résumé

Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex (MHC) molecules, and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing are yet to be fully understood. In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2

Identifiants

DOI: 10.1038/s41423-023-01083-0 PMID: 37726420 PMC: PMC10616275
pubmed: 37726420
doi: 10.1038/s41423-023-01083-0
pii: 10.1038/s41423-023-01083-0
pmc: PMC10616275
doi:

Substances chimiques

Epitopes, T-Lymphocyte 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1328-1338

Subventions

Organisme : NIAID NIH HHS
ID : 75N93019C00001
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00065
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to CSI and USTC.

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Auteurs

Tertuliano Alves Pereira Neto (TAP)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.

John Sidney (J)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.

Alba Grifoni (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA. agrifoni@lji.org.
ORCID: 0000-0002-2209-5966

Alessandro Sette (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, 92037, USA.
ORCID: 0000-0001-7013-2250

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Eucaryotes › Animaux › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Correlative CD4 and CD8 T-cell immunodominance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Correlative CD4 and CD8 T-cell immunodominance...