Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
20 09 2023
20 09 2023
Historique:
received:
23
06
2023
accepted:
05
09
2023
medline:
22
9
2023
pubmed:
21
9
2023
entrez:
20
9
2023
Statut:
epublish
Résumé
Tau (MAPT) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. Emerging evidence for non-canonical functions of Tau in DNA repair and P53 regulation suggests its involvement in cancer. To bring new evidence for a relevant role of Tau in cancer, we carried out an in-silico pan-cancer analysis of MAPT transcriptomic profile in over 10000 clinical samples from 32 cancer types and over 1300 pre-clinical samples from 28 cancer types provided by the TCGA and the DEPMAP datasets respectively. MAPT expression associated with key cancer hallmarks including inflammation, proliferation, and epithelial to mesenchymal transition, showing cancer-specific patterns. In some cancer types, MAPT functional networks were affected by P53 mutational status. We identified new associations of MAPT with clinical outcomes and drug response in a context-specific manner. Overall, our findings indicate that the MAPT gene is a potential major player in multiple types of cancer. Importantly, the impact of Tau on cancer seems to be heavily influenced by the specific cellular environment.
Identifiants
pubmed: 37730697
doi: 10.1038/s41597-023-02543-y
pii: 10.1038/s41597-023-02543-y
pmc: PMC10511431
doi:
Substances chimiques
Tumor Suppressor Protein p53
0
MAPT protein, human
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
637Informations de copyright
© 2023. Springer Nature Limited.
Références
Bioinformatics. 2010 Jun 15;26(12):1572-3
pubmed: 20427518
Ann Transl Med. 2018 May;6(10):175
pubmed: 29951497
Mol Carcinog. 2019 Jun;58(6):1056-1067
pubmed: 30790360
Cell Rep. 2021 Nov 23;37(8):109996
pubmed: 34818544
Adv Exp Med Biol. 2019;1184:135-143
pubmed: 32096035
Nat Neurosci. 2014 Mar;17(3):357-66
pubmed: 24464041
J Biol Chem. 2020 Jun 5;295(23):7970-7980
pubmed: 32345600
Reprod Med Biol. 2017 Mar 20;16(2):143-151
pubmed: 29259462
Nat Commun. 2018 Oct 16;9(1):4284
pubmed: 30327461
Nucleic Acids Res. 2003 Jan 1;31(1):334-41
pubmed: 12520017
Anticancer Res. 2015 Oct;35(10):5179-84
pubmed: 26408675
JAMA Netw Open. 2020 Nov 2;3(11):e2025515
pubmed: 33185677
Oncotarget. 2017 Jul 25;8(30):48794-48806
pubmed: 27447864
Clin Cancer Res. 2007 Apr 1;13(7):2061-7
pubmed: 17404087
Mol Neurodegener. 2021 Jun 5;16(1):37
pubmed: 34090488
Cell Mol Life Sci. 2008 Mar;65(5):700-12
pubmed: 18193162
Cancers (Basel). 2020 Dec 16;12(12):
pubmed: 33339112
Breast Cancer Res. 2011 Nov 02;13(5):R85
pubmed: 21888627
Protein Sci. 2022 Jan;31(1):8-22
pubmed: 34717010
Gen Pharmacol. 1993 Nov;24(6):1383-6
pubmed: 7906661
CA Cancer J Clin. 2014 Mar-Apr;64(2):83-103
pubmed: 24488779
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):984-9
pubmed: 24395782
Sci Transl Med. 2020 Jan 22;12(527):
pubmed: 31969485
Brain Sci. 2020 Nov 16;10(11):
pubmed: 33207722
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
J Clin Oncol. 2009 Sep 10;27(26):4287-92
pubmed: 19667268
J Neurosci. 1991 Feb;11(2):392-400
pubmed: 1899446
Front Pharmacol. 2022 Nov 23;13:1047463
pubmed: 36506566
J Biol Chem. 2011 Feb 11;286(6):4566-75
pubmed: 21131359
Sci Rep. 2018 Dec 7;8(1):17702
pubmed: 30531974
Brain. 2018 Feb 1;141(2):324-331
pubmed: 29390124
Neoplasia. 2021 Sep;23(9):912-928
pubmed: 34325342
Curr Biol. 2017 Sep 11;27(17):2652-2660.e4
pubmed: 28844647
Front Cell Neurosci. 2014 Mar 18;8:84
pubmed: 24672431
Cold Spring Harb Perspect Med. 2015 Apr 01;5(4):
pubmed: 25833940
Breast Cancer Res Treat. 2009 Jul;116(1):131-43
pubmed: 18668363
J Hematol Oncol. 2021 Jan 5;14(1):1
pubmed: 33402199
PLoS One. 2013 May 20;8(5):e63621
pubmed: 23700427
Adv Cancer Res. 2022;154:15-45
pubmed: 35459468
Am J Dermatopathol. 2014 Jan;36(1):e5-9
pubmed: 23782676
Front Cell Dev Biol. 2021 Oct 14;9:740550
pubmed: 34722523
Sci Rep. 2023 Jun 23;13(1):10208
pubmed: 37353565
Breast Cancer Res. 2010;12(3):R43
pubmed: 20579400
Eur J Pharmacol. 2021 Oct 5;908:174312
pubmed: 34245746
Clin Cancer Res. 2016 Apr 15;22(8):1932-9
pubmed: 26603258
Methods Mol Biol. 2021;2267:19-56
pubmed: 33786783
Nature. 2021 Oct;598(7880):359-363
pubmed: 34588692
Ther Adv Hematol. 2015 Aug;6(4):202-8
pubmed: 26288714
Curr Opin Pharmacol. 2011 Aug;11(4):281-7
pubmed: 21497135
Annu Rev Neurosci. 2017 Jul 25;40:189-210
pubmed: 28772101
Cell Cycle. 2018;17(21-22):2474-2483
pubmed: 30394813
J Exp Clin Cancer Res. 2013 Apr 30;32:25
pubmed: 23631819
Nucleic Acids Res. 2019 Aug 22;47(14):7294-7305
pubmed: 31251810
Mol Cell Biol. 2002 Aug;22(16):5650-61
pubmed: 12138177
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Sci Rep. 2016 Sep 08;6:33047
pubmed: 27605042
Nat Neurosci. 2019 Jan;22(1):37-46
pubmed: 30559478
Biochemistry. 2015 Feb 24;54(7):1525-33
pubmed: 25623359
Front Mol Biosci. 2020 May 13;7:63
pubmed: 32478091
Sci Rep. 2016 Aug 22;6:31758
pubmed: 27545311
Elife. 2014 May 27;3:e02200
pubmed: 24867637
Bioinformatics. 2022 Feb 7;38(5):1473-1476
pubmed: 34864890
Biochim Biophys Acta. 2011 Dec;1816(2):105-18
pubmed: 21616127
Carcinogenesis. 2019 Nov 25;40(11):1299-1307
pubmed: 31504231
Saudi J Biol Sci. 2021 Jul;28(7):3641-3649
pubmed: 34220214
ESMO Open. 2020 Oct;5(5):e000718
pubmed: 33087400
Curr Aging Sci. 2018;11(2):77-89
pubmed: 29552989
Breast. 2013 Aug;22 Suppl 2:S27-9
pubmed: 24074787
Cancers (Basel). 2022 Dec 24;15(1):
pubmed: 36612113
Contemp Oncol (Pozn). 2015;19(1A):A68-77
pubmed: 25691825
Cancer Res. 2015 May 1;75(9):1777-81
pubmed: 25795709
Eye (Lond). 2013 Feb;27(2):217-23
pubmed: 23238448
Sci Data. 2023 Sep 20;10(1):637
pubmed: 37730697
Nat Rev Immunol. 2020 Nov;20(11):651-668
pubmed: 32433532
Cell Cycle. 2014;13(24):3927-37
pubmed: 25483067
Mol Brain. 2015 Nov 24;8(1):78
pubmed: 26603284
Cell Cycle. 2014;13(19):3037-58
pubmed: 25486564
Cell. 2020 Jan 23;180(2):387-402.e16
pubmed: 31978347
Commun Biol. 2020 May 19;3(1):245
pubmed: 32427887
Genome Res. 2017 Oct;27(10):1645-1657
pubmed: 28904012
Int J Cancer. 1998 Aug 12;77(4):626-31
pubmed: 9679768
Front Aging Neurosci. 2019 Aug 30;11:231
pubmed: 31551755
Jpn J Clin Oncol. 2010 Apr;40(4):286-93
pubmed: 20085902