CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose.

Humans Fluoxetine / adverse effects Melatonin Drug Overdose Drug-Related Side Effects and Adverse Reactions Cytochrome P-450 Enzyme System / genetics Polymorphism, Genetic Seizures

Journal

South Dakota medicine : the journal of the South Dakota State Medical Association
ISSN: 0038-3317
Titre abrégé: S D Med
Pays: United States
ID NLM: 101265265

Informations de publication

Date de publication:
Jul 2023
Historique:
medline: 25 9 2023
pubmed: 21 9 2023
entrez: 21 9 2023
Statut: ppublish

Résumé

Cytochrome P450 polymorphisms have gathered much attention regarding personalized psychopharmacological care. It is well documented that these drug metabolizing enzymes lead to interpatient variability in pharmacokinetic profiles. It appears that less functional genotype may increase of risk of higher side-effect burden. Here we highlight the importance of genetic polymorphisms to potentially predict a toxicity related phenotype after an intentional overdose. Genotyping may have a role in predicting serious side effects to help clinicians educate patients and their families, and implement more intensive monitoring and institute prophylactic treatment as needed.

Identifiants

PMID: 37733961
pubmed: 37733961

Substances chimiques

Fluoxetine 01K63SUP8D
Melatonin JL5DK93RCL
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

305-308

Informations de copyright

Copyright© South Dakota State Medical Association.

Auteurs

Sarah Campbell (S)

Psychiatry Residency Program, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Hannah Otten (H)

Avera Medical Group Behavioral Health, Sioux Falls, South Dakota.
Department of Psychiatry, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Vivek Anand (V)

Avera Medical Group Behavioral Health, Sioux Falls, South Dakota.
Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Composés chimiques organiques › Amines › Propylamines › Fluoxétine › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Mélatonine › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Mésusage de médicament › Surdose › Mauvais usage des médicaments prescrits › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Troubles dus à des produits chimiques › Effets secondaires indésirables des médicaments › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › CYP450 Genetic Polymorphisms: Generalized...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › CYP450 Genetic Polymorphisms: Generalized...