PET reporter systems for the brain.

Humans Genes, Reporter Positron-Emission Tomography / methods Brain / diagnostic imaging Central Nervous System
PET imaging PET tracer central nervous system gene therapies reporter probes stem cell therapies

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
11 2023
Historique:
received: 04 04 2023
revised: 18 07 2023
accepted: 23 08 2023
pmc-release: 01 11 2024
medline: 23 10 2023
pubmed: 22 9 2023
entrez: 21 9 2023
Statut: ppublish

Résumé

Positron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer with good central nervous system (CNS) penetration and high selectivity for the target protein. This review evaluates existing methods for the visualization of reporter proteins and/or protein function using PET imaging, focusing on engineered systems, and discusses possible approaches for future success in the development of high-sensitivity and high-specificity PET reporter systems for the brain.

Identifiants

DOI: 10.1016/j.tins.2023.08.007 PMID: 37734962 PMC: PMC10592100
pubmed: 37734962
pii: S0166-2236(23)00205-9
doi: 10.1016/j.tins.2023.08.007
pmc: PMC10592100
mid: NIHMS1927419
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

941-952

Subventions

Organisme : Intramural NIH HHS
ID : Z01 MH002795
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000069
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA MH002793
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA MH002795
Pays : United States

Informations de copyright

Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of interests M.M. has received research funding from AstraZeneca, Redpin Therapeutics, Dompé Farmaceutici, and Attune Neurosciences, and is named as an inventor on a patent describing novel DREADD ligands (WO2019/157083). T.M. is named as an inventor on a patent for the use of DCZ as a PET reporter probe (WO2019/245047). The other coauthors declare no conflicts of interest.

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Auteurs

Sridhar Goud Nerella (SG)

Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sridhar.nerella@nih.gov.

Michael Michaelides (M)

Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

Takafumi Minamimoto (T)

Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

Robert B Innis (RB)

Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

Victor W Pike (VW)

Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

Mark A G Eldridge (MAG)

Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address: mark.eldridge@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PET reporter systems for the brain.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › PET reporter systems for the brain.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › PET reporter systems for the brain.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › PET reporter systems for the brain.
questionsmedicales.fr › Système nerveux › Système nerveux central › PET reporter systems for the brain.