Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML.
DAC resistance
MDS/AML
O-GlcNAc
OGT
TWIST1
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
22 09 2023
22 09 2023
Historique:
received:
29
06
2023
accepted:
14
08
2023
medline:
25
9
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
epublish
Résumé
Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacted with DNA methyltransferase 3a (DNMT3a) to regulate the decitabine (DAC) resistance in MDS/AML. However, the underlying mechanism of TWIST1 dysregulation in DAC resistance remained enigmatic. Here, we found that O-GlcNAc modification was upregulated in CD34
Identifiants
pubmed: 37736724
doi: 10.1186/s12964-023-01278-y
pii: 10.1186/s12964-023-01278-y
pmc: PMC10514931
doi:
Substances chimiques
O-GlcNAc transferase
EC 2.4.1.-
Decitabine
776B62CQ27
N-Acetylglucosaminyltransferases
EC 2.4.1.-
TWIST1 protein, human
0
Nuclear Proteins
0
Twist-Related Protein 1
0
Types de publication
Video-Audio Media
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
255Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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