Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope.
cryo-EM
fusion glycoprotein
monoclonal antibodies
neutralizing antibodies
respiratory syncytial virus
structural biology
vaccine
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
medline:
22
9
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
aheadofprint
Résumé
Respiratory syncytial virus (RSV) causes tens of millions of acute lower respiratory tract infections and millions of hospital admissions globally each year. An antibody repertoire analysis of a human vaccine trial investigating a prefusion-stabilized RSV fusion (F) glycoprotein antigen (DS-Cav1) identified several neutralizing antibody public clonotypes (PCs) in multiple vaccine recipients. Of these, PCs 1 and 2 were found in six out of six and five out of six vaccine recipients, respectively. Whereas PC1 was shown to bind antigenic site V, the binding site and mechanism of action for PC2 were not defined. Here, we expressed and characterized six antibodies from PC2 and one PC2-like antibody, which we found to be prefusion-specific, possess nanomolar affinity for RSV F, and display neutralization IC
Identifiants
pubmed: 37737588
doi: 10.1128/jvi.00929-23
pmc: PMC10617438
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0092923Références
Clin Infect Dis. 2021 Jul 1;73(1):e158-e163
pubmed: 32531019
Nat Med. 2010 Jan;16(1):123-8
pubmed: 20023635
Curr Top Microbiol Immunol. 2013;372:83-104
pubmed: 24362685
J Virol. 1988 Nov;62(11):4232-8
pubmed: 2459412
Influenza Other Respir Viruses. 2022 Nov;16(6):1151-1160
pubmed: 36069297
J Virol. 2011 Aug;85(15):7788-96
pubmed: 21613394
J Gen Virol. 1988 Oct;69 ( Pt 10):2623-8
pubmed: 3171553
Nucleic Acids Res. 2016 Jul 8;44(W1):W344-50
pubmed: 27166375
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7348-E7357
pubmed: 28807998
Nat Rev Immunol. 2023 Mar;23(3):189-199
pubmed: 36168054
Nat Commun. 2022 Mar 14;13(1):1299
pubmed: 35288548
Curr Opin Virol. 2017 Apr;23:107-112
pubmed: 28525878
Sci Transl Med. 2017 May 3;9(388):
pubmed: 28469033
J Virol. 2014 Oct;88(20):11802-10
pubmed: 25078705
Lancet. 2022 May 28;399(10340):2047-2064
pubmed: 35598608
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
Sci Transl Med. 2022 Mar 23;14(637):eabi9215
pubmed: 35133175
J Infect Dis. 1997 Nov;176(5):1215-24
pubmed: 9359721
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9619-24
pubmed: 21586636
Immunity. 2021 Apr 13;54(4):769-780.e6
pubmed: 33823129
Nucleic Acids Res. 2022 Jul 5;50(W1):W276-W279
pubmed: 35412617
Sci Transl Med. 2023 Apr 26;15(693):eade6422
pubmed: 37023209
NPJ Vaccines. 2017 Mar 8;2:7
pubmed: 29021918
Nature. 2012 Nov 15;491(7424):406-12
pubmed: 23151583
J Virol. 2021 Aug 25;95(18):e0048521
pubmed: 34160257
Front Immunol. 2012 May 08;3:87
pubmed: 22586427
Sci Transl Med. 2023 Apr 19;15(692):eade4976
pubmed: 37075126
Cell. 2019 Mar 7;176(6):1420-1431.e17
pubmed: 30849373
Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):531-544
pubmed: 29872004
J Mol Biol. 2007 May 4;368(3):652-65
pubmed: 17362988
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Curr Top Microbiol Immunol. 2013;372:59-82
pubmed: 24362684
Immunity. 2018 Feb 20;48(2):339-349.e5
pubmed: 29396163
Protein Sci. 2021 Jan;30(1):70-82
pubmed: 32881101
mBio. 2010 May 18;1(1):
pubmed: 20689752
J Mol Biol. 2007 Sep 21;372(3):774-97
pubmed: 17681537
Virus Res. 2000 Jun;68(1):25-33
pubmed: 10930660
Science. 2021 Sep 03;373(6559):1109-1116
pubmed: 34344823
J Infect Dis. 2014 Jun 15;209(12):1873-81
pubmed: 24482398
Pathog Immun. 2019 Dec 11;4(2):294-323
pubmed: 31893251
Nat Microbiol. 2017 Jan 30;2:16272
pubmed: 28134915
J Gen Virol. 2004 Dec;85(Pt 12):3677-3687
pubmed: 15557241
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Science. 2013 May 31;340(6136):1113-7
pubmed: 23618766
Cell Host Microbe. 2019 Jun 12;25(6):827-835.e6
pubmed: 31104946
Science. 2019 Aug 2;365(6452):505-509
pubmed: 31371616
Nat Commun. 2019 Sep 12;10(1):4153
pubmed: 31515478
Cell Rep. 2021 Nov 2;37(5):109929
pubmed: 34710354
N Engl J Med. 2023 Apr 20;388(16):1465-1477
pubmed: 37018468
Sci Immunol. 2022 Dec 23;7(78):eadf1421
pubmed: 36356052
Sci Immunol. 2016 Dec 16;1(6):
pubmed: 28111638
Nat Commun. 2015 Sep 03;6:8143
pubmed: 26333350
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303
pubmed: 29788355
Nat Commun. 2023 Feb 13;14(1):798
pubmed: 36781872
J Gen Virol. 1983 Apr;64 (Pt 4):825-32
pubmed: 6834007
Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):519-530
pubmed: 29872003
Nature. 2013 Sep 19;501(7467):439-43
pubmed: 23955151
IUCrJ. 2019 Jun 27;6(Pt 4):526-531
pubmed: 31316797
J Virol. 1983 Jul;47(1):171-7
pubmed: 6345804
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13961-6
pubmed: 9391135
Virol J. 2006 May 24;3:34
pubmed: 16723026
Sci Transl Med. 2015 Oct 14;7(309):309ra162
pubmed: 26468324
Protein Expr Purif. 2013 Nov;92(1):54-61
pubmed: 24012791
J Gen Virol. 1991 Dec;72 ( Pt 12):3095-101
pubmed: 1765771
J Virol. 1987 Dec;61(12):3855-61
pubmed: 3316707
Drugs. 2023 Feb;83(2):181-187
pubmed: 36577878
Nat Struct Mol Biol. 2016 Sep;23(9):811-820
pubmed: 27478931
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
N Engl J Med. 2023 Feb 16;388(7):595-608
pubmed: 36791160
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7462-6
pubmed: 3532115
Sci Transl Med. 2022 Dec 21;14(676):eade0424
pubmed: 36542692
Science. 2013 Nov 1;342(6158):592-8
pubmed: 24179220