Pharmaceutical stability of methemoglobin-albumin cluster as an antidote for hydrogen sulfide poisoning after one-year storage in freeze-dried form.
Albumin
Freeze-dry
Methemoglobin
Stability
Storage
hydrogen sulfide (H(2)S)
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 Oct 2023
15 Oct 2023
Historique:
received:
17
07
2023
revised:
23
08
2023
accepted:
19
09
2023
medline:
9
10
2023
pubmed:
23
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Long-term stability during storage is an important requirement for pharmaceutical preparations. The methemoglobin (metHb)-albumin cluster, in which bovine metHb is covalently enveloped with an average of three human albumin molecules, is a promising antidote for hydrogen sulfide (H
Identifiants
pubmed: 37739098
pii: S0378-5173(23)00854-2
doi: 10.1016/j.ijpharm.2023.123433
pii:
doi:
Substances chimiques
Methemoglobin
9008-37-1
Antidotes
0
Hydrogen Sulfide
YY9FVM7NSN
Powders
0
Albumins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123433Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.