Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury.
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
28
03
2023
accepted:
01
09
2023
pmc-release:
01
12
2024
medline:
17
11
2023
pubmed:
23
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Cardiovascular disease represents a leading cause of death, morbidity, and societal economic burden. The prevalence of cannabis use has significantly increased due to legalization and an increased societal acceptance of cannabis. Therefore, it is critically important that we gain a greater understanding of the effects and risks of cannabinoid use on cardiovascular diseases as well as the potential for cannabinoid-directed drugs to be used as therapeutics for the treatment of cardiovascular disease. This review summarizes our current understanding of the role of cannabinoid receptors in the pathophysiology of atherosclerosis and myocardial ischemia and explores their use as therapeutic targets in the treatment of ischemic heart disease. Endocannabinoids are elevated in patients with atherosclerosis, and activation of cannabinoid type 1 receptors (CB
Identifiants
pubmed: 37739804
pii: jpet.123.001665
doi: 10.1124/jpet.123.001665
pmc: PMC10658922
doi:
Substances chimiques
Cannabinoids
0
Endocannabinoids
0
Cannabinoid Receptor Agonists
0
Receptors, Cannabinoid
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-276Subventions
Organisme : NIDA NIH HHS
ID : R01 DA044999
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL145546
Pays : United States
Informations de copyright
Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.
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