Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease.
Allergy
Asthma
Atopy
COPD
IgE
Staphylococcal enterotoxin A and B
Staphylococcus aureus
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
received:
27
05
2023
accepted:
22
08
2023
medline:
25
9
2023
pubmed:
23
9
2023
entrez:
22
9
2023
Statut:
epublish
Résumé
Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in serum SEA-IgE and SEB-IgE levels between patients with chronic obstructive pulmonary disease (COPD), asthma, and controls, and to assess the association between SE sensitization and COPD clinical parameters and Th2 inflammation biomarkers in two well-defined COPD cohorts. Our findings suggest that COPD patients do not exhibit higher SEA and SEB sensitization compared to asthma patients and controls. However, in COPD patients, the presence of atopy and allergy is associated with positivity for SEA-IgE and SEB-IgE. Consequently, these allergens may aid in identifying atopic or allergic subgroups within the COPD population, but they are not directly associated with the diagnosis of COPD, elevated circulating blood eosinophils, or fractional exhaled nitric oxide (FENO) levels.
Identifiants
pubmed: 37740199
doi: 10.1186/s12931-023-02520-4
pii: 10.1186/s12931-023-02520-4
pmc: PMC10517478
doi:
Substances chimiques
Enterotoxins
0
Immunoglobulin E
37341-29-0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
225Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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