Sensitive spectrofluorimetric determination of the prokinetic drug prucalopride succinate based on supramolecular aggregation approach with evaluation of method greenness: application to content uniformity test.

content uniformity testing method greenness prokinetic drug spectrofluorimetry supramolecular aggregation

Journal

Luminescence : the journal of biological and chemical luminescence
ISSN: 1522-7243
Titre abrégé: Luminescence
Pays: England
ID NLM: 100889025

Informations de publication

Date de publication:
Dec 2023
Historique:
revised: 24 08 2023
received: 29 07 2023
accepted: 18 09 2023
medline: 5 12 2023
pubmed: 23 9 2023
entrez: 23 9 2023
Statut: ppublish

Résumé

The prokinetic drug, prucalopride (PCP) succinate, was determined using a new spectrofluorimetric approach with a highly sensitive, rapid, and simple procedure. The method exploited the enhancement of the inherent native fluorescence of PCP by micellar aggregation with sodium lauryl sulfate (SLS) as an anionic surfactant. Different factors that could affect the fluorescence intensity were carefully studied in order to achieve the maximal fluorescence signal. Measurement of the enhanced fluorescence was done at 354 nm after the excitation at 276 nm. The fluorescence intensity-concentration plot was rectilinear in the concentration range of 50-600 ng/ml with detection and quantitation limits of 13.9 and 42.1 ng/ml, respectively. The method underwent validation according to the International Council for Harmonisation criteria in order to assess its analytical performance, and promising results were achieved that proved the validity and reliability of the method. Furthermore, the method was employed effectively for the analysis of the cited drug in commercial pharmaceutical tablets.

Identifiants

pubmed: 37740522
doi: 10.1002/bio.4597
doi:

Substances chimiques

prucalopride 0A09IUW5TP
Succinates 0
Tablets 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2065-2072

Informations de copyright

© 2023 John Wiley & Sons Ltd.

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Auteurs

Sayed M Derayea (SM)

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Fatma F Mohammed (FF)

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Khalid M Badr El-Din (KM)

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

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