Rules and mechanisms governing G protein coupling selectivity of GPCRs.

Receptors, G-Protein-Coupled / metabolism GTP-Binding Proteins / metabolism Signal Transduction / physiology Carrier Proteins / metabolism Algorithms
BRET assay CP: Cell biology G protein GEF activity GPCR Gα classification genetic variation signaling bias systems biology

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
31 10 2023
Historique:
received: 08 09 2022
revised: 21 06 2023
accepted: 07 09 2023
medline: 6 11 2023
pubmed: 24 9 2023
entrez: 24 9 2023
Statut: ppublish

Résumé

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: G

Identifiants

DOI: 10.1016/j.celrep.2023.113173 PMID: 37742189
pubmed: 37742189
pii: S2211-1247(23)01185-3
doi: 10.1016/j.celrep.2023.113173
pii:
doi:

Substances chimiques

Receptors, G-Protein-Coupled 0
GTP-Binding Proteins EC 3.6.1.-
Carrier Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113173

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests K.A.M. is a co-founder, advisor, and stockholder of EvoDenovo, Inc., and Blueshield Therapeutics, Inc., biotechnology companies that pursue development of therapeutics, which are not related to the results described in this study.

Auteurs

Ikuo Masuho (I)

Department of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA. Electronic address: ikuo.masuho@sanfordhealth.org.

Ryoji Kise (R)

Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.

Pablo Gainza (P)

Laboratory of Protein Design and Immunoengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Ee Von Moo (E)

Department of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA.

Xiaona Li (X)

Department of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA.

Ryosuke Tany (R)

Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.

Hideko Wakasugi-Masuho (H)

Department of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.

Bruno E Correia (BE)

Laboratory of Protein Design and Immunoengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Kirill A Martemyanov (KA)

Department of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA. Electronic address: kmartemyanov@ufl.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Rules and mechanisms governing G protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Rules and mechanisms governing G protein...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Rules and mechanisms governing G protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Rules and mechanisms governing G protein...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Rules and mechanisms governing G protein...