Cytotoxic innate intraepithelial lymphocytes control early stages of
cryptosporidium
cytotoxicity
gut
innate intraepithelial lymphocytes
organoids
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
31
07
2023
medline:
26
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Intraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as To better define functions of innate IELs in cryptosporidiosis, we developed a co-culture model with innate IELs isolated from Thanks to this original model, we demonstrated that innate IELs control parasite proliferation. We further showed that although innate IELs secrete IFN-γ in response to Based on these data we conclude that innate IELs, most likely T-cell-like innate IELs, provide a rapid protection against
Sections du résumé
Background
Intraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as
Methods
To better define functions of innate IELs in cryptosporidiosis, we developed a co-culture model with innate IELs isolated from
Results
Thanks to this original model, we demonstrated that innate IELs control parasite proliferation. We further showed that although innate IELs secrete IFN-γ in response to
Conclusion
Based on these data we conclude that innate IELs, most likely T-cell-like innate IELs, provide a rapid protection against
Identifiants
pubmed: 37744354
doi: 10.3389/fimmu.2023.1229406
pmc: PMC10512070
doi:
Substances chimiques
Granzymes
EC 3.4.21.-
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229406Informations de copyright
Copyright © 2023 Hariss, Delbeke, Guyot, Zarnitzky, Ezzedine, Certad and Meresse.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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