mSphere of Influence: Virology in the noise-how cell-to-cell variability impacts viral infection outcomes.
HSV-1
herpes
single cell
virus
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
24 10 2023
24 10 2023
Historique:
medline:
25
10
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Nir Drayman works at the intersection of virology and single-cell biology, studying how cellular heterogeneity shapes the outcome of viral infections (and specifically that of HSV-1). In this mSphere of Influence article, he reflects on how two papers, "Remote activation of host cell DNA synthesis in uninfected cells signaled by infected cells in advance of virus transmission" (N. Schmidt, T. Hennig, R. A. Serwa, M. Marchetti, and P. O'Hare, J Virol 89:11107-11115, 2015, https://doi.org/10.1128/jvi.01950-15) and "Extreme heterogeneity of influenza virus infection in single cells" (A. B. Russell, C. Trapnell, and J. D. Bloom, Elife 7:e32303, 2018, https://doi.org/10.7554/eLife.32303), impacted his research by trail blazing the analysis of viral infections in single cells, as well as by illuminating what is yet left to discover.
Identifiants
pubmed: 37747254
doi: 10.1128/msphere.00438-23
pmc: PMC10597340
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0043823Subventions
Organisme : HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : DP2AI154437
Commentaires et corrections
Type : CommentOn
Type : CommentOn
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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