Nir Drayman

Affiliations

The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.

Publications (20)

Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed

Chemical communications (Cambridge, England)

Avec: Aaron Morris , William McCorkindale , The Covid Moonshot Consortium , Nir Drayman , John D Chodera , Savaş Tay , Nir London , Alpha A Lee

Dissecting viral infections, one cell at a time, by single-cell technologies.

Microbes and infection

Avec: Pierre Bost , Nir Drayman

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

Nature biotechnology

Avec: Yadi Zhou , Yuan Liu , Shagun Gupta , Mauricio I Paramo , Yuan Hou , Chengsheng Mao , Yuan Luo , Julius Judd , Shayne Wierbowski , Marta Bertolotti , Mriganka Nerkar , Lara Jehi , Nir Drayman , Vlad Nicolaescu , Haley Gula , Savaş Tay , Glenn Randall , Peihui Wang , John T Lis , Cédric Feschotte , Serpil C Erzurum , Feixiong Cheng , Haiyuan Yu

A drug repurposing screen identifies decitabine as an HSV-1 antiviral.

Microbiology spectrum

Avec: Laura Bautista , Cody Sirimanotham , Jason Espinoza , Dillon Cheng , Savaş Tay , Nir Drayman

Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Enosh Tomer , Efrat M Cohen , Nir Drayman , Amichay Afriat , Matthew D Weitzman , Assaf Zaritsky , Oren Kobiler

Fixed single-cell RNA sequencing for understanding virus infection and host response.

bioRxiv : the preprint server for biology

Avec: Hoang Van Phan , Michiel van Gent , Nir Drayman , Anindita Basu , Michaela U Gack , Savaş Tay

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells.

bioRxiv : the preprint server for biology

Avec: Long C Nguyen , David M Renner , Diane Silva , Dongbo Yang , Nicholas Parenti , Kaeri M Medina , Vlad Nicolaescu , Haley Gula , Nir Drayman , Andrea Valdespino , Adil Mohamed , Christopher Dann , Kristin Wannemo , Lydia Robinson-Mailman , Alan Gonzalez , Letícia Stock , Mengrui Cao , Zeyu Qiao , Raymond E Moellering , Savas Tay , Glenn Randall , Michael F Beers , Marsha Rich Rosner , Scott A Oakes , Susan R Weiss

Shared sequence characteristics identified in non-canonical rearrangements of HSV-1 genomes.

Journal of virology

Avec: Alina Shitrit , Valerya Nisnevich , Nofar Rozenshtein , Hila Kobo , Hoang Van Phan , Savaş Tay , Moriah Szpara , Matthew D Weitzman , Nir Drayman , Oren Kobiler

Ultra-sensitive digital quantification of proteins and mRNA in single cells.

Nature communications

Avec: Jing Lin , Christian Jordi , Minjun Son , Hoang Van Phan , Nir Drayman , Mustafa Fatih Abasiyanik , Luke Vistain , Hsiung-Lin Tu , Savaş Tay

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2

bioRxiv : the preprint server for biology

Avec: Nir Drayman , Krysten A Jones , Saara-Anne Azizi , Heather M Froggatt , Kemin Tan , Natalia Ivanovna Maltseva , Siquan Chen , Vlad Nicolaescu , Steve Dvorkin , Kevin Furlong , Rahul S Kathayat , Mason R Firpo , Vincent Mastrodomenico , Emily A Bruce , Madaline M Schmidt , Robert Jedrzejczak , Miguel Á Muñoz-Alía , Brooke Schuster , Vishnu Nair , Jason W Botten , Christopher B Brooke , Susan C Baker , Bryan C Mounce , Nicholas S Heaton , Bryan C Dickinson , Andrzej Jaochimiak , Glenn Randall , Savaş Tay

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

Science (New York, N.Y.)

Avec: Nir Drayman , Jennifer K DeMarco , Krysten A Jones , Saara-Anne Azizi , Heather M Froggatt , Kemin Tan , Natalia Ivanovna Maltseva , Siquan Chen , Vlad Nicolaescu , Steve Dvorkin , Kevin Furlong , Rahul S Kathayat , Mason R Firpo , Vincent Mastrodomenico , Emily A Bruce , Madaline M Schmidt , Robert Jedrzejczak , Miguel Á Muñoz-Alía , Brooke Schuster , Vishnu Nair , Kyu-Yeon Han , Amornrat O'Brien , Anastasia Tomatsidou , Bjoern Meyer , Marco Vignuzzi , Dominique Missiakas , Jason W Botten , Christopher B Brooke , Hyun Lee , Susan C Baker , Bryan C Mounce , Nicholas S Heaton , William E Severson , Kenneth E Palmer , Bryan C Dickinson , Andrzej Joachimiak , Glenn Randall , Savaş Tay

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.

Science advances

Avec: Long Chi Nguyen , Dongbo Yang , Vlad Nicolaescu , Thomas J Best , Haley Gula , Divyasha Saxena , Jon D Gabbard , Shao-Nong Chen , Takashi Ohtsuki , John Brent Friesen , Nir Drayman , Adil Mohamed , Christopher Dann , Diane Silva , Lydia Robinson-Mailman , Andrea Valdespino , Letícia Stock , Eva Suárez , Krysten A Jones , Saara-Anne Azizi , Jennifer K Demarco , William E Severson , Charles D Anderson , James Michael Millis , Bryan C Dickinson , Savaş Tay , Scott A Oakes , Guido F Pauli , Kenneth E Palmer , Auteur inconnu , David O Meltzer , Glenn Randall , Marsha Rich Rosner

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19.

Research square

Avec: Yadi Zhou , Yuan Liu , Shagun Gupta , Mauricio I Paramo , Yuan Hou , Chengsheng Mao , Yuan Luo , Julius Judd , Shayne Wierbowski , Marta Bertolotti , Mriganka Nerkar , Lara Jehi , Nir Drayman , Vlad Nicolaescu , Haley Gula , Savaş Tay , Glenn Randall , John T Lis , Cédric Feschotte , Serpil C Erzurum , Feixiong Cheng , Haiyuan Yu

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.

mBio

Avec: Long C Nguyen , David M Renner , Diane Silva , Dongbo Yang , Nicholas A Parenti , Kaeri M Medina , Vlad Nicolaescu , Haley Gula , Nir Drayman , Andrea Valdespino , Adil Mohamed , Christopher Dann , Kristin Wannemo , Lydia Robinson-Mailman , Alan Gonzalez , Letícia Stock , Mengrui Cao , Zeyu Qiao , Raymond E Moellering , Savas Tay , Glenn Randall , Michael F Beers , Marsha Rich Rosner , Scott A Oakes , Susan R Weiss

HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations.

eLife

Avec: Nir Drayman , Parthiv Patel , Luke Vistain , Savaş Tay

Computer vision reveals hidden variables underlying NF-κB activation in single cells.

Science advances

Avec: Parthiv Patel , Nir Drayman , Ping Liu , Mustafa Bilgic , Savaş Tay

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.

bioRxiv : the preprint server for biology

Avec: Long Chi Nguyen , Dongbo Yang , Vlad Nicolaescu , Thomas J Best , Takashi Ohtsuki , Shao-Nong Chen , J Brent Friesen , Nir Drayman , Adil Mohamed , Christopher Dann , Diane Silva , Haley Gula , Krysten A Jones , J Michael Millis , Bryan C Dickinson , Savaş Tay , Scott A Oakes , Guido F Pauli , David O Meltzer , Glenn Randall , Marsha Rich Rosner

High-throughput RNA sequencing of paraformaldehyde-fixed single cells.

Nature communications

Avec: Hoang Van Phan , Michiel van Gent , Nir Drayman , Anindita Basu , Michaela U Gack , Savaş Tay

mSphere of Influence: Virology in the noise-how cell-to-cell variability impacts viral infection outcomes.

mSphere

Avec: Nir Drayman

Herpesviruses mimic zygotic genome activation to promote viral replication.

Research square

Avec: Florian Full , Stephanie Walter , Eva Neugebauer , Jiang Tan , Nir Drayman , Vedran Franke , Savaş Tay , Markus Landthaler , Altuna Akalin , Armin Ensser , Emanuel Wyler

Réseau de co-auteurs

Savaş Tay 15 collaborations

Vlad Nicolaescu 8 collaborations

Glenn Randall 8 collaborations

Haley Gula 6 collaborations

Hoang Van Phan 4 collaborations

Diane Silva 4 collaborations

Dongbo Yang 4 collaborations

Adil Mohamed 4 collaborations

Christopher Dann 4 collaborations

Marsha Rich Rosner 4 collaborations

Scott A Oakes 4 collaborations

Krysten A Jones 4 collaborations

Bryan C Dickinson 4 collaborations

Andrea Valdespino 3 collaborations

Lydia Robinson-Mailman 3 collaborations

Letícia Stock 3 collaborations

Saara-Anne Azizi 3 collaborations

Yadi Zhou 2 collaborations

Yuan Liu 2 collaborations

Shagun Gupta 2 collaborations

Mauricio I Paramo 2 collaborations

Yuan Hou 2 collaborations

Chengsheng Mao 2 collaborations

Yuan Luo 2 collaborations

Julius Judd 2 collaborations

Shayne Wierbowski 2 collaborations

Marta Bertolotti 2 collaborations

Mriganka Nerkar 2 collaborations

Lara Jehi 2 collaborations

John T Lis 2 collaborations

Cédric Feschotte 2 collaborations

Serpil C Erzurum 2 collaborations

Feixiong Cheng 2 collaborations

Haiyuan Yu 2 collaborations

Matthew D Weitzman 2 collaborations

Oren Kobiler 2 collaborations

Michiel van Gent 2 collaborations

Anindita Basu 2 collaborations

Michaela U Gack 2 collaborations

Long C Nguyen 2 collaborations

David M Renner 2 collaborations

Kaeri M Medina 2 collaborations

Kristin Wannemo 2 collaborations

Alan Gonzalez 2 collaborations

Mengrui Cao 2 collaborations

Zeyu Qiao 2 collaborations

Raymond E Moellering 2 collaborations

Savas Tay 2 collaborations

Michael F Beers 2 collaborations

Susan R Weiss 2 collaborations

Luke Vistain 2 collaborations

Heather M Froggatt 2 collaborations

Kemin Tan 2 collaborations

Natalia Ivanovna Maltseva 2 collaborations

Siquan Chen 2 collaborations

Steve Dvorkin 2 collaborations

Kevin Furlong 2 collaborations

Rahul S Kathayat 2 collaborations

Mason R Firpo 2 collaborations

Vincent Mastrodomenico 2 collaborations

Emily A Bruce 2 collaborations

Madaline M Schmidt 2 collaborations

Robert Jedrzejczak 2 collaborations

Miguel Á Muñoz-Alía 2 collaborations

Brooke Schuster 2 collaborations

Vishnu Nair 2 collaborations

Jason W Botten 2 collaborations

Christopher B Brooke 2 collaborations

Susan C Baker 2 collaborations

Bryan C Mounce 2 collaborations

Nicholas S Heaton 2 collaborations

William E Severson 2 collaborations

Kenneth E Palmer 2 collaborations

Long Chi Nguyen 2 collaborations

Thomas J Best 2 collaborations

Shao-Nong Chen 2 collaborations

Takashi Ohtsuki 2 collaborations

Guido F Pauli 2 collaborations

David O Meltzer 2 collaborations

Parthiv Patel 2 collaborations

Aaron Morris 1 collaboration

William McCorkindale 1 collaboration

The Covid Moonshot Consortium 1 collaboration

John D Chodera 1 collaboration

Nir London 1 collaboration

Alpha A Lee 1 collaboration

Pierre Bost 1 collaboration

Peihui Wang 1 collaboration

Laura Bautista 1 collaboration

Cody Sirimanotham 1 collaboration

Jason Espinoza 1 collaboration

Dillon Cheng 1 collaboration

Enosh Tomer 1 collaboration

Efrat M Cohen 1 collaboration

Amichay Afriat 1 collaboration

Assaf Zaritsky 1 collaboration

Nicholas Parenti 1 collaboration

Alina Shitrit 1 collaboration

Valerya Nisnevich 1 collaboration

Nofar Rozenshtein 1 collaboration

Hila Kobo 1 collaboration

Moriah Szpara 1 collaboration

Jing Lin 1 collaboration

Christian Jordi 1 collaboration

Minjun Son 1 collaboration

Mustafa Fatih Abasiyanik 1 collaboration

Hsiung-Lin Tu 1 collaboration

Andrzej Jaochimiak 1 collaboration

Jennifer K DeMarco 1 collaboration

Kyu-Yeon Han 1 collaboration

Amornrat O'Brien 1 collaboration

Anastasia Tomatsidou 1 collaboration

Bjoern Meyer 1 collaboration

Marco Vignuzzi 1 collaboration

Dominique Missiakas 1 collaboration

Hyun Lee 1 collaboration

Andrzej Joachimiak 1 collaboration

Divyasha Saxena 1 collaboration

Jon D Gabbard 1 collaboration

John Brent Friesen 1 collaboration

Eva Suárez 1 collaboration

Jennifer K Demarco 1 collaboration

Charles D Anderson 1 collaboration

James Michael Millis 1 collaboration

None None 1 collaboration

Nicholas A Parenti 1 collaboration

Ping Liu 1 collaboration

Mustafa Bilgic 1 collaboration

J Brent Friesen 1 collaboration

J Michael Millis 1 collaboration

Florian Full 1 collaboration

Stephanie Walter 1 collaboration

Eva Neugebauer 1 collaboration

Jiang Tan 1 collaboration

Vedran Franke 1 collaboration

Markus Landthaler 1 collaboration

Altuna Akalin 1 collaboration

Armin Ensser 1 collaboration

Emanuel Wyler 1 collaboration