Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients.

Humans Aged Middle Aged Adolescent Young Adult Adult Kidney Transplantation / adverse effects Living Donors Graft Survival Graft Rejection / etiology HLA Antigens Risk Factors
HLA-incompatible clinical research/practice kidney transplantation living donor older outcomes

Journal

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 05 04 2023
revised: 26 08 2023
accepted: 18 09 2023
medline: 4 12 2023
pubmed: 26 9 2023
entrez: 25 9 2023
Statut: ppublish

Résumé

Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transplant (ILDKT) recipients who undergo desensitization and intense immunosuppression. In a 25-center cohort of ILDKT recipients transplanted between September 24, 1997, and December 15, 2016, we compared mortality, DCGF, delayed graft function (DGF), acute rejection (AR), and length of stay (LOS) between 234 older (age ≥60 years) and 1172 younger (age 18-59 years) recipients. To investigate whether the impact of age was different for ILDKT recipients compared to 17 542 CLDKT recipients, we used an interaction term to determine whether the relationship between posttransplant outcomes and transplant type (ILDKT vs CLDKT) was modified by age. Overall, older recipients had higher mortality (hazard ratio:

Identifiants

DOI: 10.1016/j.ajt.2023.09.010 PMID: 37748554
pubmed: 37748554
pii: S1600-6135(23)00698-6
doi: 10.1016/j.ajt.2023.09.010
pii:
doi:

Substances chimiques

HLA Antigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1980-1989

Informations de copyright

Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.

Auteurs

Jane J Long (JJ)

Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Jennifer D Motter (JD)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA.

Kyle R Jackson (KR)

Department of Surgery, Emory University, Atlanta, Georgia, USA.

Jennifer Chen (J)

Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

Babak J Orandi (BJ)

Department of Surgery, University of Alabama, Birmingham, Alabama, USA.

Robert A Montgomery (RA)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA.

Mark D Stegall (MD)

Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Stanley C Jordan (SC)

Department of Medicine, Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California, USA.

Enrico Benedetti (E)

Department of Surgery, University of Illinois-Chicago, Chicago, Illinois, USA.

Ty B Dunn (TB)

Department of Surgery, University of Pennsylvania, Philadelphia, Philadelphia, USA.

Lloyd E Ratner (LE)

Department of Surgery, Columbia University Medical Center, New York, New York, USA.

Sandip Kapur (S)

Department of Surgery, New York Presbyterian/Weill Cornell Medical Center, New York, New York, USA.

Ronald P Pelletier (RP)

Department of Surgery, Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA.

John P Roberts (JP)

Department of Surgery, University of California-San Francisco, San Francisco, California, USA.

Marc L Melcher (ML)

Department of Surgery, Stanford University, Palo Alto, California, USA.

Pooja Singh (P)

Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, Philadelphia, USA.

Debra L Sudan (DL)

Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Marc P Posner (MP)

Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.

Jose M El-Amm (JM)

Integris Baptist Medical Center, Transplant Division, Oklahoma City, Oklahoma, USA.

Ron Shapiro (R)

Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.

Matthew Cooper (M)

Medstar Georgetown Transplant Institute, Washington, District of Columbia, USA.

Jennifer E Verbesey (JE)

Medstar Georgetown Transplant Institute, Washington, District of Columbia, USA.

George S Lipkowitz (GS)

Department of Surgery, Baystate Medical Center Springfield, Massachusetts, Massachusetts, USA.

Michael A Rees (MA)

Department of Urology, University of Toledo Medical Center, Toledo, Ohio, USA.

Christopher L Marsh (CL)

Department of Surgery, Scripps Clinic and Green Hospital, La Jolla, California, USA.

Bashir R Sankari (BR)

Department of Urology, Cleveland Clinic, Cleveland, Ohio, USA.

David A Gerber (DA)

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Jason R Wellen (JR)

Department of Surgery, Barnes-Jewish Hospital, St. Louis, Missouri, USA.

Adel Bozorgzadeh (A)

Department of Surgery, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, USA.

A Osama Gaber (AO)

Department of Surgery, Houston Methodist Hospital, Houston, Texas, USA.

Eliot C Heher (EC)

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Francis L Weng (FL)

Renal and Pancreas Transplant Division, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.

Arjang Djamali (A)

Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.

J Harold Helderman (JH)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Beatrice P Concepcion (BP)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Kenneth L Brayman (KL)

Department of Surgery, University of Virginia, Charlottesville, Virginia, USA.

Jose Oberholzer (J)

Department of Surgery, University of Virginia, Charlottesville, Virginia, USA.

Tomasz Kozlowski (T)

Department of Surgery, University of Florida, Gainesville, Florida, USA.

Karina Covarrubias (K)

Department of Surgery, University of California San Diego, San Diego, California, USA.

Allan B Massie (AB)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.

Mara A McAdams-DeMarco (MA)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.

Dorry L Segev (DL)

Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA; Scientific Registry of Transplant Recipients, Minneapolis, Minnesota, USA.

Jacqueline M Garonzik-Wang (JM)

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, USA. Electronic address: garonzikwang@wisc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Personnes › Donneurs de tissus › Donneur vivant › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Characterizing the risk of human leukocyte...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Characterizing the risk of human leukocyte...