Rapid droplet-based mixing for single-molecule spectroscopy.


Journal

Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 27 02 2023
accepted: 02 08 2023
pubmed: 26 9 2023
medline: 26 9 2023
entrez: 25 9 2023
Statut: ppublish

Résumé

Probing non-equilibrium dynamics with single-molecule spectroscopy is important for dissecting biomolecular mechanisms. However, existing microfluidic rapid-mixing systems for this purpose are incompatible with surface-adhesive biomolecules, exhibit undesirable flow dispersion and are often demanding to fabricate. Here we introduce droplet-based microfluidic mixing for single-molecule spectroscopy to overcome these limitations in a wide range of applications. We demonstrate its robust functionality with binding kinetics of even very surface-adhesive proteins on the millisecond timescale.

Identifiants

pubmed: 37749213
doi: 10.1038/s41592-023-01995-9
pii: 10.1038/s41592-023-01995-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1479-1482

Subventions

Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : #NNF18OC0033926

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Tianjin Yang (T)

Department of Biochemistry, University of Zurich, Zurich, Switzerland. t.yang@bioc.uzh.ch.

Karin J Buholzer (KJ)

Department of Biochemistry, University of Zurich, Zurich, Switzerland.

Andrea Sottini (A)

Department of Biochemistry, University of Zurich, Zurich, Switzerland.

Xiaobao Cao (X)

Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.

Andrew deMello (A)

Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.

Daniel Nettels (D)

Department of Biochemistry, University of Zurich, Zurich, Switzerland.

Benjamin Schuler (B)

Department of Biochemistry, University of Zurich, Zurich, Switzerland. schuler@bioc.uzh.ch.
Department of Physics, University of Zurich, Zurich, Switzerland. schuler@bioc.uzh.ch.

Classifications MeSH