Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T

Humans Crohn Disease / microbiology CD4-Positive T-Lymphocytes Inflammatory Bowel Diseases / pathology T-Lymphocytes, Helper-Inducer Clone Cells / pathology Intestinal Mucosa / pathology Th17 Cells / pathology Th1 Cells / pathology

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
10 2023
Historique:
received: 08 03 2023
accepted: 22 08 2023
medline: 23 10 2023
pubmed: 26 9 2023
entrez: 25 9 2023
Statut: ppublish

Résumé

Aberrant CD4

Identifiants

DOI: 10.1038/s41591-023-02556-5 PMID: 37749331 PMC: PMC10579100
pubmed: 37749331
doi: 10.1038/s41591-023-02556-5
pii: 10.1038/s41591-023-02556-5
pmc: PMC10579100
mid: EMS188949
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2602-2614

Subventions

Organisme : European Research Council
ID : 101040023
Pays : International
Organisme : NIH HHS
ID : R01DK121977
Pays : United States
Organisme : NIH HHS
ID : R01AI163007
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Gabriela Rios Martini (GR)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Ekaterina Tikhonova (E)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Elisa Rosati (E)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0002-2635-6422

Meghan Bialt DeCelie (MB)

The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Laura Katharina Sievers (LK)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0002-4677-5181

Florian Tran (F)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0002-3735-9872

Matthias Lessing (M)

Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Arne Bergfeld (A)

Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Sophia Hinz (S)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Susanna Nikolaus (S)

Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Julia Kümpers (J)

Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Anna Matysiak (A)

Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Philipp Hofmann (P)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Carina Saggau (C)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Stephan Schneiders (S)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0001-9208-3330

Ann-Kristin Kamps (AK)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Gunnar Jacobs (G)

Institute of Epidemiology, Christian-Albrechts-University of Kiel and popgen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany.

Wolfgang Lieb (W)

Institute of Epidemiology, Christian-Albrechts-University of Kiel and popgen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0003-2544-4460

Jochen Maul (J)

Gastroenterologie am Bayerischen Platz, Berlin, Germany.
Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Britta Siegmund (B)

Department of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
ORCID: 0000-0002-0055-958X

Barbara Seegers (B)

Gastroenterology-Hepatology Center Kiel, Kiel, Germany.

Holger Hinrichsen (H)

Gastroenterology-Hepatology Center Kiel, Kiel, Germany.

Hans-Heinrich Oberg (HH)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Daniela Wesch (D)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Stefan Bereswill (S)

Institute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Markus M Heimesaat (MM)

Institute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Jan Rupp (J)

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
ORCID: 0000-0001-8722-1233

Olaf Kniemeyer (O)

Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
ORCID: 0000-0002-9493-6402

Axel A Brakhage (AA)

Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
Friedrich Schiller Universität, Jena, Germany.
ORCID: 0000-0002-8814-4193

Sascha Brunke (S)

Institute of Microbiology, Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
ORCID: 0000-0001-7740-4570

Bernhard Hube (B)

Friedrich Schiller Universität, Jena, Germany.
Institute of Microbiology, Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.

Konrad Aden (K)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0003-3482-7316

Andre Franke (A)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Iliyan D Iliev (ID)

The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
ORCID: 0000-0003-0884-9749

Alexander Scheffold (A)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0002-0626-343X

Stefan Schreiber (S)

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.

Petra Bacher (P)

Institute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. p.bacher@ikmb.uni-kiel.de.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. p.bacher@ikmb.uni-kiel.de.
ORCID: 0000-0003-4264-6451

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Selection of cross-reactive T cells by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Selection of cross-reactive T cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Selection of cross-reactive T cells by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Selection of cross-reactive T cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Selection of cross-reactive T cells by...
questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › Selection of cross-reactive T cells by...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Selection of cross-reactive T cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Selection of cross-reactive T cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Selection of cross-reactive T cells by...