Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level- an observational sub-analysis fit- COVID study.
SARS-CoV-2
immune response
inflammation
metabolism
physical activity
post-acute COVID-19 syndrome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
04
2023
accepted:
10
08
2023
medline:
28
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
This study aimed to evaluate if physical activity is associated with systemic and cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. Mild- to- moderate post-COVID-19 patients (70.50 ± 43.10 days of diagnosis; age: 29.4 (21.9- 34.9) years; BMI: 25.5 ± 4.3 kg m The post-COVID-19 group exhibited lower levels of moderate to vigorous physical activity (MVPA) (p = 0.038); therefore, all study comparisons were performed with adjustment for MVPA. Post-COVID-19 impacted the pulmonary function (FEV1, FEV1%pred, FVC, and FVC %pred) compared with the control (p adjusted by MVPA (p adj) <0.05). Post-COVID-19 exhibited lower levels of serum IL-6 (p adj <0.01), whereas it showed higher serum IL-10, triglyceride, leptin, IgG, ACE activity, TNFRSF1A, and PGE Young adults after mild-to-moderate SARS-CoV-2 infection appeared to have lower physical activity levels, which can be associated with clinical and immunometabolic responses in a complex manner.
Identifiants
pubmed: 37753077
doi: 10.3389/fimmu.2023.1212745
pmc: PMC10518618
doi:
Substances chimiques
Interleukin-10
130068-27-8
Interleukin-6
0
Leptin
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1212745Informations de copyright
Copyright © 2023 Silva, Pereira, Minuzzi, Padilha, Figueiredo, Olean-Oliveira, dos Santos, von Ah Morano, Marchioto Júnior, Ribeiro, Dos Santos, Seelaender, Teixeira, Dos Santos, Lemos, Freire, Dorneles, Marmett, Olean-Oliveira, Teixeira, Seraphim, Caseiro, Pinho, Islam, Little, Krüger, Rosa-Neto, Coelho-E-Silva and Lira.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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