Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses.
defense response
mechanism
phytopathogenic bacteria
repurpose drugs
salicylamide
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
26
07
2023
accepted:
25
09
2023
medline:
29
11
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
Based on the research strategy of "drug repurposing", a series of derivatives and marketed drugs that containing salicylic acid skeleton were tested for their antibacterial activities against phytopathogens. Salicylic acid can not only regulate some important growth metabolism of plants, but also induce plant disease resistance. The bioassay results showed that the salicylamides exhibited excellent antibacterial activity. Especially, oxyclozanide showed the best antibacterial effect against Xanthomonas oryzae, Xanthomonas axonopodis pv. citri and Pectobacterium atroseptica with MICs of 0.78, 3.12 and 12.5 μg.mL-1, respectively. In vivo experiments with rice bacterial leaf blight had further demonstrated that oxyclozanide exhibited stronger antibacterial activity than the commercial bactericide, thiodiazole copper. Oxyclozanide could induce plant defense responses through the determination of salicylic acid content and the activities of defense-related enzymes including CAT, POD, and SOD in rice. The preliminarily antibacterial mechanism study indicated that oxyclozanide exhibited the antibacterial activity by disrupting cell integrity and reducing bacterial pathogenicity. Additionally, oxyclozanide could induce plant defense responses through the determination of salicylic acid content.
Identifiants
pubmed: 37755070
doi: 10.1002/cbdv.202300998
doi:
Substances chimiques
Salicylamides
0
Oxyclozanide
1QS9G4876X
Anti-Bacterial Agents
0
Salicylic Acid
O414PZ4LPZ
Oxadiazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300998Subventions
Organisme : National Natural Science Foundation of China
ID : 22177043
Organisme : National Natural Science Foundation of China
ID : 21877056
Organisme : Natural Science Foundation of Gansu Province
ID : 20JR5RA311
Informations de copyright
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
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