Activation of a Silent Polyketide Synthase SlPKS4 Encoding the C

Simplicillium lamellicola genome mining isocoumarins nonreducing polyketide synthase (nrPKS) silent gene clusters

Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
13 Sep 2023
Historique:
received: 24 08 2023
revised: 06 09 2023
accepted: 12 09 2023
medline: 28 9 2023
pubmed: 27 9 2023
entrez: 27 9 2023
Statut: epublish

Résumé

Coumarins, isocoumarins and their derivatives are polyketides abundant in fungal metabolites. Although they were first discovered over 50 years ago, the biosynthetic process is still not entirely understood. Herein, we report the activation of a silent nonreducing polyketide synthase that encodes a C

Identifiants

pubmed: 37755103
pii: md21090490
doi: 10.3390/md21090490
pmc: PMC10532586
pii:
doi:

Substances chimiques

Isocoumarins 0
Polyketide Synthases 79956-01-7
Coumarins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Jing Yu (J)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Xiaolin Liu (X)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Chuanteng Ma (C)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Chen Li (C)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Yuhan Zhang (Y)

School of Pharmaceutical Science, Shandong University, Jinan 250100, China.

Qian Che (Q)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Guojian Zhang (G)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.

Tianjiao Zhu (T)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Dehai Li (D)

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.

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Classifications MeSH